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Rational design and synthesis of flavonolactam derivatives as potent topo I inhibitors with antitumor activity.

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Title: Rational design and synthesis of flavonolactam derivatives as potent topo I inhibitors with antitumor activity.
Authors: Shi X; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Huang Y; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Yang X; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Wang M; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Han X; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Yang S; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Li W; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China., Jia J; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China. Electronic address: jiajingming@163.com., Wang A; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China. Electronic address: sywanganhua@163.com., Huang S; Department of Head and Neck Surgery, Stomatological Hospital of China Medical University, Shenyang, 110002, People's Republic of China. Electronic address: huangshaohui@hotmail.com.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Jul 05; Vol. 311, pp. 118804. Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Rational design and synthesis of flavonolactam derivatives as potent topo I inhibitors with antitumor activity.
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  Data: <searchLink fieldCode="AU" term="%22Shi+X%22">Shi X</searchLink>; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Han+X%22">Han X</searchLink>; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Jia+J%22">Jia J</searchLink>; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China. Electronic address: jiajingming@163.com.<br /><searchLink fieldCode="AU" term="%22Wang+A%22">Wang A</searchLink>; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China. Electronic address: sywanganhua@163.com.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Department of Head and Neck Surgery, Stomatological Hospital of China Medical University, Shenyang, 110002, People's Republic of China. Electronic address: huangshaohui@hotmail.com.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Jul 05; Vol. 311, pp. 118804. <i>Date of Electronic Publication: </i>2026 Mar 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejmech.2026.118804
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        Text: English
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        StartPage: 118804
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            – D: 05
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              Text: 2026 Jul 05
              Type: published
              Y: 2026
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