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Therapeutic potential of phytocannabinoids in depression and cognitive dysfunction: Evidence from preclinical models.

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Title: Therapeutic potential of phytocannabinoids in depression and cognitive dysfunction: Evidence from preclinical models.
Authors: Fonseca C; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona 08028, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona 08035, Spain., Gouveia F; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona 08028, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona 08035, Spain., Silva S; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal., Castanheira S; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal., Driouech L; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona 08028, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona 08035, Spain; Department Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Barcelona 08028, Spain., Matos AM; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; Chemical Engineering and Renewable Resources for Sustainability, CERES, Faculty of Pharmacy, University of Coimbra, Coimbra 3000-570, Portugal., Barbosa RM; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal., Camins A; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona 08028, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona 08035, Spain; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Carlos III Health Institute, Madrid 28031, Spain., Falcão A; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal., Ettcheto M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona 08028, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona 08035, Spain; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Carlos III Health Institute, Madrid 28031, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus 43204, Spain., Fortuna A; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal. Electronic address: afortuna@ff.uc.pt.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 May; Vol. 198, pp. 119298. Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Fonseca+C%22">Fonseca C</searchLink>; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona 08028, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona 08035, Spain.<br /><searchLink fieldCode="AU" term="%22Gouveia+F%22">Gouveia F</searchLink>; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona 08028, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona 08035, Spain.<br /><searchLink fieldCode="AU" term="%22Silva+S%22">Silva S</searchLink>; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal.<br /><searchLink fieldCode="AU" term="%22Castanheira+S%22">Castanheira S</searchLink>; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal.<br /><searchLink fieldCode="AU" term="%22Driouech+L%22">Driouech L</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona 08028, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona 08035, Spain; Department Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Barcelona 08028, Spain.<br /><searchLink fieldCode="AU" term="%22Matos+AM%22">Matos AM</searchLink>; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; Chemical Engineering and Renewable Resources for Sustainability, CERES, Faculty of Pharmacy, University of Coimbra, Coimbra 3000-570, Portugal.<br /><searchLink fieldCode="AU" term="%22Barbosa+RM%22">Barbosa RM</searchLink>; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal.<br /><searchLink fieldCode="AU" term="%22Camins+A%22">Camins A</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona 08028, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona 08035, Spain; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Carlos III Health Institute, Madrid 28031, Spain.<br /><searchLink fieldCode="AU" term="%22Falcão+A%22">Falcão A</searchLink>; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal.<br /><searchLink fieldCode="AU" term="%22Ettcheto+M%22">Ettcheto M</searchLink>; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona 08028, Spain; Institute of Neurosciences, Universitat de Barcelona, Barcelona 08035, Spain; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Carlos III Health Institute, Madrid 28031, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus 43204, Spain.<br /><searchLink fieldCode="AU" term="%22Fortuna+A%22">Fortuna A</searchLink>; Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Health Sciences Center, Azinhaga de Santa Comba, Coimbra 3000-548, Portugal; CIBIT, ICNAS, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra 3000-548, Portugal. Electronic address: afortuna@ff.uc.pt.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2026 May; Vol. 198, pp. 119298. <i>Date of Electronic Publication: </i>2026 Apr 03.
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