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Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes.

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Title: Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes.
Authors: Kim C; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA.; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, USA.; Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Republic of Korea., Bu F; Department of Biostatistics, University of Michigan, Ann Arbor, USA., Blacketer C; Johnson and Johnson, New Brunswick, USA., Ostropolets A; Johnson and Johnson, New Brunswick, USA., Duarte-Salles T; Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, Spain.; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands., Viernes B; VA Informatics and Computing Infrastructure, United States Department of Veterans Affairs, Salt Lake City, USA., Falconer T; Department of Biomedical Informatics, Columbia University, New York, USA., Pistillo A; Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, Spain., Li J; Real World Solutions, IQVIA, Shanghai, China., Yin C; Real World Solutions, IQVIA, Shanghai, China., Van Zandt M; Real World Solutions, IQVIA, Durham, USA., Nagy P; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, USA., Nishimura A; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA., Minty E; O'Brien Institute for Public Health, University of Calgary, Calgary, Canada., You SC; Department of Biomedicine Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea., Sawano M; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, USA., Sawano S; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, USA., Jeon JY; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea., Aminorroaya A; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA., Dhingra LS; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA., Pedroso AF; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA., Thangaraj P; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA., Dorr DA; Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, Portland, USA., Pratt N; Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Man KKC; Research Department of Practice and Policy, UCL School of Pharmacy, London, United Kingdom., Lau WCY; Research Department of Practice and Policy, UCL School of Pharmacy, London, United Kingdom., Morales DR; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, USA., Khera R; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA.; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, USA., Schuemie MJ; Johnson and Johnson, New Brunswick, USA., Ryan PB; Johnson and Johnson, New Brunswick, USA.; Department of Biomedical Informatics, Columbia University, New York, USA., Hripcsak G; VA Informatics and Computing Infrastructure, United States Department of Veterans Affairs, Salt Lake City, USA.; Department of Biomedical Informatics, Columbia University, New York, USA., Krumholz HM; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA.; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, USA., Suchard MA; VA Informatics and Computing Infrastructure, United States Department of Veterans Affairs, Salt Lake City, USA. msuchard@ucla.edu.; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, USA. msuchard@ucla.edu., Lu Y; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA. y.lu@yale.edu.; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, USA. y.lu@yale.edu.
Source: Nature communications [Nat Commun] 2026 Apr 04; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 04.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Kim+C%22">Kim C</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA.; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, USA.; Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Bu+F%22">Bu F</searchLink>; Department of Biostatistics, University of Michigan, Ann Arbor, USA.<br /><searchLink fieldCode="AU" term="%22Blacketer+C%22">Blacketer C</searchLink>; Johnson and Johnson, New Brunswick, USA.<br /><searchLink fieldCode="AU" term="%22Ostropolets+A%22">Ostropolets A</searchLink>; Johnson and Johnson, New Brunswick, USA.<br /><searchLink fieldCode="AU" term="%22Duarte-Salles+T%22">Duarte-Salles T</searchLink>; Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, Spain.; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Viernes+B%22">Viernes B</searchLink>; 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VA Informatics and Computing Infrastructure, United States Department of Veterans Affairs, Salt Lake City, USA.; Department of Biomedical Informatics, Columbia University, New York, USA.<br /><searchLink fieldCode="AU" term="%22Krumholz+HM%22">Krumholz HM</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA.; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, USA.<br /><searchLink fieldCode="AU" term="%22Suchard+MA%22">Suchard MA</searchLink>; VA Informatics and Computing Infrastructure, United States Department of Veterans Affairs, Salt Lake City, USA. msuchard@ucla.edu.; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, USA. msuchard@ucla.edu.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, USA. y.lu@yale.edu.; 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