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SETDB1 modulates neuroinflammation in the mouse cortex by regulating neuronal P2rx7 expression.

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Title: SETDB1 modulates neuroinflammation in the mouse cortex by regulating neuronal P2rx7 expression.
Authors: Zhu Y; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Liao L; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Liu X; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Sheng H; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Sun D; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Li J; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Chen Q; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Zhang C; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Wang S; Huashan Hospital, Fudan University, 200040, Shanghai, China., Zhang Y; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Weng J; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Zhou M; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Yang J; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Dong Y; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Peng W; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China., Li Y; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China. yue_li@fudan.edu.cn., Jiang Y; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China. yan_jiang@fudan.edu.cn.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Aug; Vol. 31 (8), pp. 4741-4758. Date of Electronic Publication: 2026 Apr 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SETDB1 modulates neuroinflammation in the mouse cortex by regulating neuronal P2rx7 expression.
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  Data: <searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liao+L%22">Liao L</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Sheng+H%22">Sheng H</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Sun+D%22">Sun D</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Huashan Hospital, Fudan University, 200040, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Weng+J%22">Weng J</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhou+M%22">Zhou M</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Dong+Y%22">Dong Y</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Peng+W%22">Peng W</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China. yue_li@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, 200032, Shanghai, China. yan_jiang@fudan.edu.cn.
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        Value: 10.1038/s41380-026-03584-6
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