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Impact of TP53 alterations on outcomes in pediatric and young adult patients with relapsed / refractory B-cell acute lymphoblastic leukemia after CD19-CAR T-Cell therapy.

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Title: Impact of TP53 alterations on outcomes in pediatric and young adult patients with relapsed / refractory B-cell acute lymphoblastic leukemia after CD19-CAR T-Cell therapy.
Authors: Alonso-Saladrigues A; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.; PhD student. Faculty of Medicine. Universitat de Barcelona, Barcelona, Spain., Esperanza-Cebollada E; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain., Vicente-Garcés C; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain., Perez-Jaume S; Biostatistics and Mathematics Research Unit, Sant Joan de Déu Pediatric Cancer Center Barcelona, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.; Biostatistics Unit, Department of Basic Clinical Practice, Universitat de Barcelona, Barcelona, Spain., Sánchez-Sierra N; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain., Richarte-Franqués M; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain., Català A; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain., Crespo-Carrasco A; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain., Dapena JL; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain., Cuatrecasas Capdevila E; Cytogenetics Laboratory. Laboratory Diagnostic Service. Hospital Sant Joan de Déu de Barcelona, Esplugues de Llobregat, Barcelona, Spain., Faura Morros A; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain., Ruiz-Cobo MA; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain., Arqués L; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain., Conde Cuevas N; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain., Andreu S; Cytogenetics Laboratory. Laboratory Diagnostic Service. Hospital Sant Joan de Déu de Barcelona, Esplugues de Llobregat, Barcelona, Spain., Isola I; Hematology Laboratory, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain., Jordan I; Pediatric Intensive Care Unit, Hospital Sant Joan de Déu de Barcelona, University of Barcelona, Esplugues de Llobregat, Barcelona, Spain.; Immunological and Respiratory Disfunction in Pediatric Critical Patient Research Group, Institut de Recerca Sant Joan de Déu. Consorcio de Investigación Biomédica en Red de Epidemiología y Salud (CIBERESP), Madrid, Spain., García-Rey E; Apheresis Unit, Banc de Sang i Teixits, Barcelona, Spain., Llanos C; Clinical Research Unit, Fundació Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Marsal J; Stem Cell Transplant Unit. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain., Celis V; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain., Camós M; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Hematology Laboratory, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain., Torrebadell M; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Hematology Laboratory, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain., Vega-García N; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain. nerea.vega@sjd.es.; Hematology Laboratory, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain. nerea.vega@sjd.es., Rives S; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain. susana.rives@sjd.es.; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain. susana.rives@sjd.es.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain. susana.rives@sjd.es.
Source: Bone marrow transplantation [Bone Marrow Transplant] 2026 Jun; Vol. 61 (6), pp. 685-693. Date of Electronic Publication: 2026 Apr 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8702459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5365 (Electronic) Linking ISSN: 02683369 NLM ISO Abbreviation: Bone Marrow Transplant Subsets: MEDLINE
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  Data: Impact of TP53 alterations on outcomes in pediatric and young adult patients with relapsed / refractory B-cell acute lymphoblastic leukemia after CD19-CAR T-Cell therapy.
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  Data: <searchLink fieldCode="AU" term="%22Alonso-Saladrigues+A%22">Alonso-Saladrigues A</searchLink>; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.; PhD student. Faculty of Medicine. Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Esperanza-Cebollada+E%22">Esperanza-Cebollada E</searchLink>; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vicente-Garcés+C%22">Vicente-Garcés C</searchLink>; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Perez-Jaume+S%22">Perez-Jaume S</searchLink>; Biostatistics and Mathematics Research Unit, Sant Joan de Déu Pediatric Cancer Center Barcelona, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.; Biostatistics Unit, Department of Basic Clinical Practice, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez-Sierra+N%22">Sánchez-Sierra N</searchLink>; CAR T-cell Unit. 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Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Crespo-Carrasco+A%22">Crespo-Carrasco A</searchLink>; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Dapena+JL%22">Dapena JL</searchLink>; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cuatrecasas+Capdevila+E%22">Cuatrecasas Capdevila E</searchLink>; Cytogenetics Laboratory. Laboratory Diagnostic Service. Hospital Sant Joan de Déu de Barcelona, Esplugues de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Faura+Morros+A%22">Faura Morros A</searchLink>; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ruiz-Cobo+MA%22">Ruiz-Cobo MA</searchLink>; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arqués+L%22">Arqués L</searchLink>; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Conde+Cuevas+N%22">Conde Cuevas N</searchLink>; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Andreu+S%22">Andreu S</searchLink>; Cytogenetics Laboratory. Laboratory Diagnostic Service. Hospital Sant Joan de Déu de Barcelona, Esplugues de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Isola+I%22">Isola I</searchLink>; Hematology Laboratory, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Jordan+I%22">Jordan I</searchLink>; Pediatric Intensive Care Unit, Hospital Sant Joan de Déu de Barcelona, University of Barcelona, Esplugues de Llobregat, Barcelona, Spain.; Immunological and Respiratory Disfunction in Pediatric Critical Patient Research Group, Institut de Recerca Sant Joan de Déu. Consorcio de Investigación Biomédica en Red de Epidemiología y Salud (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22García-Rey+E%22">García-Rey E</searchLink>; Apheresis Unit, Banc de Sang i Teixits, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Llanos+C%22">Llanos C</searchLink>; Clinical Research Unit, Fundació Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Marsal+J%22">Marsal J</searchLink>; Stem Cell Transplant Unit. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Celis+V%22">Celis V</searchLink>; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Camós+M%22">Camós M</searchLink>; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Hematology Laboratory, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Torrebadell+M%22">Torrebadell M</searchLink>; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Hematology Laboratory, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vega-García+N%22">Vega-García N</searchLink>; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain. nerea.vega@sjd.es.; Hematology Laboratory, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain. nerea.vega@sjd.es.<br /><searchLink fieldCode="AU" term="%22Rives+S%22">Rives S</searchLink>; CAR T-cell Unit. Leukemia and Lymphoma Department. Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain. susana.rives@sjd.es.; Leukemia and Pediatric Hematology Disorders, Developmental Tumors Biology Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain. susana.rives@sjd.es.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain. susana.rives@sjd.es.
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