View in EDS

An in vivo CRISPR screen unveils promising target genes to improve CAR-T cell efficacy in a solid tumor model.

Saved in:
Bibliographic Details
Title: An in vivo CRISPR screen unveils promising target genes to improve CAR-T cell efficacy in a solid tumor model.
Authors: Fumagalli M; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France; Thèse Financée par la Ligue Nationale Contre le Cancer, Paris, France. Electronic address: fumatia97@gmail.com., An D; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France., Simula L; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France., Combe C; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France., Aziez L; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France., Simoni Y; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France., Alves-Guerra MC; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France., Valentini A; Technical University of Denmark, 2800 Kongens Lyngby, Denmark., Marchais M; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France., Vermare A; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France., Moraly J; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Manni S; Department of Onco-Haematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy., Quadraccia MC; Department of Onco-Haematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy., Quintarelli C; Department of Onco-Haematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy; Department of Clinical Medicine and Surgery, Federico II University of Naples, 80131 Naples, Italy., De Angelis B; Department of Onco-Haematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy., Bercovici N; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France., Donnadieu E; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France., Pendino F; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France. Electronic address: frederic.pendino@inserm.fr.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jul 01; Vol. 34 (7), pp. 3976-4000. Date of Electronic Publication: 2026 Apr 04.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41935953
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: An in vivo CRISPR screen unveils promising target genes to improve CAR-T cell efficacy in a solid tumor model.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Fumagalli+M%22">Fumagalli M</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France; Thèse Financée par la Ligue Nationale Contre le Cancer, Paris, France. Electronic address: fumatia97@gmail.com.<br /><searchLink fieldCode="AU" term="%22An+D%22">An D</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France.<br /><searchLink fieldCode="AU" term="%22Simula+L%22">Simula L</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France.<br /><searchLink fieldCode="AU" term="%22Combe+C%22">Combe C</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France.<br /><searchLink fieldCode="AU" term="%22Aziez+L%22">Aziez L</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France.<br /><searchLink fieldCode="AU" term="%22Simoni+Y%22">Simoni Y</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France.<br /><searchLink fieldCode="AU" term="%22Alves-Guerra+MC%22">Alves-Guerra MC</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France.<br /><searchLink fieldCode="AU" term="%22Valentini+A%22">Valentini A</searchLink>; Technical University of Denmark, 2800 Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Marchais+M%22">Marchais M</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France.<br /><searchLink fieldCode="AU" term="%22Vermare+A%22">Vermare A</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France.<br /><searchLink fieldCode="AU" term="%22Moraly+J%22">Moraly J</searchLink>; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Manni+S%22">Manni S</searchLink>; Department of Onco-Haematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Quadraccia+MC%22">Quadraccia MC</searchLink>; Department of Onco-Haematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Quintarelli+C%22">Quintarelli C</searchLink>; Department of Onco-Haematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy; Department of Clinical Medicine and Surgery, Federico II University of Naples, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22De+Angelis+B%22">De Angelis B</searchLink>; Department of Onco-Haematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bercovici+N%22">Bercovici N</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France.<br /><searchLink fieldCode="AU" term="%22Donnadieu+E%22">Donnadieu E</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France.<br /><searchLink fieldCode="AU" term="%22Pendino+F%22">Pendino F</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014 Paris, France; Equipe Labélisée Ligue Nationale Contre le Cancer, Paris, France. Electronic address: frederic.pendino@inserm.fr.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 Jul 01; Vol. 34 (7), pp. 3976-4000. <i>Date of Electronic Publication: </i>2026 Apr 04.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41935953
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.ymthe.2026.04.009
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 3976
    Titles:
      – TitleFull: An in vivo CRISPR screen unveils promising target genes to improve CAR-T cell efficacy in a solid tumor model.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fumagalli M
      – PersonEntity:
          Name:
            NameFull: An D
      – PersonEntity:
          Name:
            NameFull: Simula L
      – PersonEntity:
          Name:
            NameFull: Combe C
      – PersonEntity:
          Name:
            NameFull: Aziez L
      – PersonEntity:
          Name:
            NameFull: Simoni Y
      – PersonEntity:
          Name:
            NameFull: Alves-Guerra MC
      – PersonEntity:
          Name:
            NameFull: Valentini A
      – PersonEntity:
          Name:
            NameFull: Marchais M
      – PersonEntity:
          Name:
            NameFull: Vermare A
      – PersonEntity:
          Name:
            NameFull: Moraly J
      – PersonEntity:
          Name:
            NameFull: Manni S
      – PersonEntity:
          Name:
            NameFull: Quadraccia MC
      – PersonEntity:
          Name:
            NameFull: Quintarelli C
      – PersonEntity:
          Name:
            NameFull: De Angelis B
      – PersonEntity:
          Name:
            NameFull: Bercovici N
      – PersonEntity:
          Name:
            NameFull: Donnadieu E
      – PersonEntity:
          Name:
            NameFull: Pendino F
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: 2026 Jul 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1525-0024
          Numbering:
            – Type: volume
              Value: 34
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Molecular therapy : the journal of the American Society of Gene Therapy
              Type: main
ResultId 1