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Astrocytic FABP5 drives non-cell-autonomous oligodendrocyte injury in multiple system atrophy by promoting TNF signaling and ferroptotic stress.

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Title: Astrocytic FABP5 drives non-cell-autonomous oligodendrocyte injury in multiple system atrophy by promoting TNF signaling and ferroptotic stress.
Authors: Wu C; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China. Electronic address: chengan@mail.sysu.edu.cn., Lin J; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China., Chen Y; Department of Industrial Engineering & Decision Analytics, Hong Kong University of Science and Technology, 999077, Hong Kong., Takahashi N; Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University Graduate School of Medicine, Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan., Chen Q; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China., Liu B; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China., Dai F; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China., Zhao W; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China., Finkelstein DI; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3010, Australia., Kawahata I; Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University Graduate School of Medicine, Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan; Department of Pharmacology, University of Shizuoka, Shizuoka, 422-8526, Japan. Electronic address: kawahata@u-shizuoka-ken.ac.jp., Fukunaga K; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, 980-8578, Japan. Electronic address: kfukunaga@tohoku.ac.jp., Cheng A; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China. Electronic address: leon.an.cheng.1q84@gmail.com.
Source: Redox biology [Redox Biol] 2026 Jun; Vol. 93, pp. 104150. Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
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  Data: Astrocytic FABP5 drives non-cell-autonomous oligodendrocyte injury in multiple system atrophy by promoting TNF signaling and ferroptotic stress.
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  Data: <searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China. Electronic address: chengan@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Industrial Engineering & Decision Analytics, Hong Kong University of Science and Technology, 999077, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Takahashi+N%22">Takahashi N</searchLink>; Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University Graduate School of Medicine, Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China.<br /><searchLink fieldCode="AU" term="%22Liu+B%22">Liu B</searchLink>; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China.<br /><searchLink fieldCode="AU" term="%22Dai+F%22">Dai F</searchLink>; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China.<br /><searchLink fieldCode="AU" term="%22Finkelstein+DI%22">Finkelstein DI</searchLink>; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Kawahata+I%22">Kawahata I</searchLink>; Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University Graduate School of Medicine, Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan; Department of Pharmacology, University of Shizuoka, Shizuoka, 422-8526, Japan. Electronic address: kawahata@u-shizuoka-ken.ac.jp.<br /><searchLink fieldCode="AU" term="%22Fukunaga+K%22">Fukunaga K</searchLink>; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, 980-8578, Japan. Electronic address: kfukunaga@tohoku.ac.jp.<br /><searchLink fieldCode="AU" term="%22Cheng+A%22">Cheng A</searchLink>; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, China. Electronic address: leon.an.cheng.1q84@gmail.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2C+B%2EV%22">Elsevier, B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101605639 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2317 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132317%22">22132317 </searchLink><i>NLM ISO Abbreviation: </i>Redox Biol <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun
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