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Risk factors for early-onset and late-onset dementia: a prospective cohort study.

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Title: Risk factors for early-onset and late-onset dementia: a prospective cohort study.
Authors: Giorgio K; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA., Stephen JJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Mansolf M; Department of Medical Social Science, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Peterson EA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Gross AL; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Briceño EM; Department of Physical Medicine & Rehabilitation, University of Michigan Medical School, Ann Arbor, MI, USA., Levine DA; Department of Internal Medicine, Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Helmer C; Bordeaux Population Health, University of Bordeaux, INSERM U1219, Bordeaux, France., Debette S; Bordeaux Population Health, University of Bordeaux, INSERM U1219, Bordeaux, France., Soumaré A; Bordeaux Population Health, University of Bordeaux, INSERM U1219, Bordeaux, France., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands., Wolters FJ; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands., Seshadri S; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; The Framingham Heart Study, Framingham, MA, USA., Satizabal CL; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; The Framingham Heart Study, Framingham, MA, USA., Himali JJ; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; The Framingham Heart Study, Framingham, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Launer LJ; National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Li D; National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Mbangdadji D; National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Lloyd-Jones DM; The Framingham Heart Study, Framingham, MA, USA; Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Sorond FA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Zhao L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Lopez OL; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Judd SE; Departments of Health Behavior and Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Hughes TM; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Guðnason V; Icelandic Heart Association, Kopavoguar, Iceland; Faculty of Medicine, University of Reykjavik, Reykjavik, Iceland., Aiello AE; Robert N Butler Columbia Aging Center, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Fohner A; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA., Singh-Manoux A; Université Paris Cité, Inserm 1153, Paris, France; Faculty of Brain Sciences, University College London, UK., Sabayan B; Department of Neurology, Hennepin Healthcare Research Institute, Hennepin County Medical Center, Minneapolis, MN, USA; Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA., Pankow JS; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Yaffe K; Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, San Francisco, CA, USA., Beiser A; The Framingham Heart Study, Framingham, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Dehghan A; Imperial College London School of Public Health, London, UK; UK Dementia Research Institute at Imperial College London, London, UK., Zmora R; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Scholtens D; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Lutsey PL; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA., Allen NB; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., MacLehose R; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA., Sedaghat S; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA. Electronic address: sedaghat@umn.edu.
Source: The lancet. Healthy longevity [Lancet Healthy Longev] 2026 Mar; Vol. 7 (3), pp. 100831. Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101773309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-7568 (Electronic) Linking ISSN: 26667568 NLM ISO Abbreviation: Lancet Healthy Longev Subsets: MEDLINE
Database: MEDLINE Ultimate
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Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Judd+SE%22">Judd SE</searchLink>; Departments of Health Behavior and Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Hughes+TM%22">Hughes TM</searchLink>; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22Guðnason+V%22">Guðnason V</searchLink>; Icelandic Heart Association, Kopavoguar, Iceland; Faculty of Medicine, University of Reykjavik, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Aiello+AE%22">Aiello AE</searchLink>; Robert N Butler Columbia Aging Center, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fohner+A%22">Fohner A</searchLink>; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Singh-Manoux+A%22">Singh-Manoux A</searchLink>; Université Paris Cité, Inserm 1153, Paris, France; Faculty of Brain Sciences, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Sabayan+B%22">Sabayan B</searchLink>; Department of Neurology, Hennepin Healthcare Research Institute, Hennepin County Medical Center, Minneapolis, MN, USA; Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pankow+JS%22">Pankow JS</searchLink>; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22de+Vries+PS%22">de Vries PS</searchLink>; Human Genetics Center, Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yaffe+K%22">Yaffe K</searchLink>; Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Beiser+A%22">Beiser A</searchLink>; 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Electronic address: sedaghat@umn.edu.
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