2025 Inborn errors of immunity practice parameter: Guidance from the Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI) and the Clinical Immunology Society (CIS).

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Title: 2025 Inborn errors of immunity practice parameter: Guidance from the Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI) and the Clinical Immunology Society (CIS).
Authors: Orange JS; Division of Allergy and Immunology, Department of Pediatrics, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, PA. Electronic address: orange@chop.edu., Chinen J; Division of Immunology, Allergy and Retrovirology, Department of Pediatrics, Baylor College of Medicine, Houston and The Woodlands, TX., Horner CC; Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University, St. Louis, MO., Kobrynski LJ; Division of Allergy and Immunology, Department of Pediatrics, Emory University, Atlanta, GA., Ballow M; Division of Pediatric Allergy and Immunology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL., Butte MJ; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA., Chandrakasan S; Division of Hematology and Oncology, Department of Pediatrics, Emory University, Atlanta, GA., Chinn IK; Division of Immunology, Allergy and Retrovirology, Department of Pediatrics, Baylor College of Medicine, Houston and The Woodlands, TX., Satter LF; Division of Immunology, Allergy and Retrovirology, Department of Pediatrics, Baylor College of Medicine, Houston and The Woodlands, TX., Freeman AF; Laboratory of Clinical Immunology and Microbiology, National Institutes of Allergy and Infectious Diseases, Bethesda, MD., Heimall JR; Division of Allergy and Immunology, Department of Pediatrics, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, PA., Knight V; Division of Allergy and Immunology, Department of Pediatrics, University of Colorado, Aurora, CO., Lawrence MG; Division of Asthma, Allergy and Immunology, Department of Medicine, University of Virginia, Charlottesville, VA., Lehman HK; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, State University of New York at Buffalo, Buffalo, NY., Maglione PJ; Pulmonary Center, Section of Pulmonary, Allergy, Sleep & Critical Care Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA., Perez EE; Institute for Asthma and Allergy, North Palm Beach, FL., Risma KA; Division of Allergy and Immunology, Department of Pediatrics at University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Walter JE; Division of Pediatric Allergy and Immunology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL; Division of Allergy and Immunology, Department of Medicine, Johns Hopkins All Children's Hospital, St Petersburg, FL., Abraham RS; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital Department of Pathology, Ohio State University College of Medicine, Columbus, OH., Barmettler S; Division of Allergy and Clinical Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Broderick L; Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, University of California San Diego, La Jolla, CA., Chang CC; Division of Immunology, Allergy and Rheumatology, Joe DiMaggio Children's Hospital, Memorial Healthcare System, Hollywood, FL., Chan AY; Division of Allergy, Immunology and Bone Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA., Chen K; Division of Immunology, Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, WA., Connelly J; Division of Hematology and Oncology, Department of Pediatrics, Vanderbilt University, Nashville, TN., Danziger-Isakov LA; Division of Infectious Diseases, Department of Pediatrics at University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., De la Morena MT; Division of Immunology, Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, WA., DiGiacomo D; Pediatric Allergy and Immunology, Jersey Shore University Medical Center, Neptune, NJ., Dimitriades VR; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of California, Davis, Sacramento, CA., Dorsey MJ; Division of Allergy, Immunology and Bone Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA., Dulek DE; Division of Pediatric Infectious Diseases, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN., Dutmer CM; Division of Allergy and Immunology, Department of Pediatrics, Emory University, Atlanta, GA., Dvorak CC; Division of Allergy, Immunology and Bone Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA., Farmer JR; Division of Allergy and Immunology, Department of Medicine, Lahey Hospital & Medical Center, UMass Chan Medical School, Burlington, MA., Frazer-Abel A; Division of Rheumatology, Department of Medicine, University of Colorado, Aurora, CO., Joshi AY; Division of Allergy and Immunology, Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, MN., Keller MD; Division of Allergy & Immunology, Children's National Hospital, Washington DC., Khan YW; Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN., Kitcharoensakkul M; Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University, St. Louis, MO., Leiding JW; Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD; Institute for Clinical and Translational Research and Cancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL., Myers KC; Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, University of Cincinnati, Cincinnati, OH., Nandakumar V; Division of Rheumatology, Department of Medicine, University of Colorado, Aurora, CO., Platt CD; Division of Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA., Pai SY; Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD., Patel NC; Division of Allergy and Immunology, Department of Pediatrics, Duke University, Durham, NC., Pozos TC; Department of Clinical Immunology, Children's Minnesota, Minneapolis, MN., Puck JM; Division of Allergy, Immunology and Bone Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA., Rider NL; Department of Pediatrics, Section of Allergy-Immunology, The Carilion Clinic, Roanoke, VA., Sacco KA; Division of Pulmonary, Allergy, and Sleep Medicine, Mayo Clinic, Jacksonville, FL., Williams KW; Division of Allergy and Immunology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC., Lieberman JA; Division of Allergy and Immunology, Department of Pediatrics, University of Tennessee, Memphis, TN., Rank MA; Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic School of Medicine, Scottsdale and Phoenix, AZ., Shaker MS; Section of Allergy and Immunology, Department of Medicine, Darmouth School of Medicine, Lebanon, NH., Abrams EM; Section of Allergy and Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada., Bernstein JA; University of Cincinnati College of Medicine, Department of Internal Medicine Division of Rheumatology, Allergy and Immunology, Cincinnati, OH., Chu DK; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada., Ellis AK; Division of Allergy and Immunology, Department of Medicine, Queen's University, Kingston, Ontario, Canada., Golden DBK; Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD., Greenhawt M; Asthma and Allergy Foundation of America, Arlington, VA., Ledford DK; Morsani College of Medicine, University of South Florida and James A. Haley Veterans' Affairs Hospital, Tampa, FL., Mosnaim G; Allergy and Immunology, North Shore University Health System, Evanston, IL., Wang J; Division of Pediatric Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York City, NY.
Source: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2026 Apr; Vol. 136 (4), pp. 426-493.e1.
Publication Type: Journal Article; Practice Guideline
Journal Info: Publisher: American College of Allergy, Asthma, and Immunology Country of Publication: United States NLM ID: 9503580 Publication Model: Print Cited Medium: Internet ISSN: 1534-4436 (Electronic) Linking ISSN: 10811206 NLM ISO Abbreviation: Ann Allergy Asthma Immunol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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      – PersonEntity:
          Name:
            NameFull: Khan YW
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            NameFull: Kitcharoensakkul M
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            NameFull: Leiding JW
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            NameFull: Pozos TC
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            NameFull: Williams KW
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            NameFull: Abrams EM
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            NameFull: Ledford DK
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            NameFull: Mosnaim G
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          Dates:
            – D: 01
              M: 04
              Text: 2026 Apr
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1534-4436
          Numbering:
            – Type: volume
              Value: 136
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
              Type: main
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