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An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease.

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Title: An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease.
Authors: Gao W; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Medical Scientist Training Program, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu., Hu P; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Present Address: Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306, China., Wick B; Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, 95060, USA., Qiu Q; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA., Zhang H; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA., Li Y; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA., Kang X; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA., Bedi K; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Haeussler M; Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, 95060, USA., Sasaki K; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, 19104, USA., Margulies K; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Wu H; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.
Source: Genome biology [Genome Biol] 2026 Apr 06; Vol. 27 (1). Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE
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  Data: An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease.
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  Data: <searchLink fieldCode="AU" term="%22Gao+W%22">Gao W</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.; Medical Scientist Training Program, University of Pennsylvania, Philadelphia, PA, 19104, USA. William.Gao@Pennmedicine.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Hu+P%22">Hu P</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Present Address: Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306, China.<br /><searchLink fieldCode="AU" term="%22Wick+B%22">Wick B</searchLink>; Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, 95060, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+Q%22">Qiu Q</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Kang+X%22">Kang X</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Bedi+K%22">Bedi K</searchLink>; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Haeussler+M%22">Haeussler M</searchLink>; Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, 95060, USA.<br /><searchLink fieldCode="AU" term="%22Sasaki+K%22">Sasaki K</searchLink>; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Margulies+K%22">Margulies K</searchLink>; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.; Penn Institute of Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA. haowu2@pennmedicine.upenn.edu.
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  Data: <searchLink fieldCode="JN" term="%22100960660%22">Genome biology</searchLink> [Genome Biol] 2026 Apr 06; Vol. 27 (1). <i>Date of Electronic Publication: </i>2026 Apr 06.
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        Value: 10.1186/s13059-026-04061-7
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        Text: English
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      – TitleFull: An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease.
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              Text: 2026 Apr 06
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