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Integrative Multi-Omics and Single-Cell Analysis Reveal THOC3 and THOC7 as Oncogenic RNA Processing Regulators in Lung Adenocarcinoma.

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Title: Integrative Multi-Omics and Single-Cell Analysis Reveal THOC3 and THOC7 as Oncogenic RNA Processing Regulators in Lung Adenocarcinoma.
Authors: Kumar S; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences Himachal Pradesh 173229, India., Wu CC; Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan., Solomon DD; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Yogananda School of AI Computers and Data Sciences, Shoolini University Solan 173229, India., Yen MC; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Yeh IJ; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Ko CC; Department of Medical Imaging, Chi-Mei Medical Center, Tainan 710402, Taiwan.; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan., Xuan DTM; Van Lang University, 69/68 Dang Thuy Tram Street, Binh Loi Trung Ward, Ho Chi Minh City, Vietnam., Chang KF; School of Medicine, National Defense Medical University, Taipei 11490, Taiwan.; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, National Defense Medical University, Kaohsiung 80284, Taiwan., Lin HR; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Nursing Department, Kaohsiung Armed Forces General Hospital, National Defense Medical University, Kaohsiung, 80284, Taiwan., Lin HY; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.; Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan.; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA., Shih CL; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 60002, Taiwan., Chen JB; Department of Radiology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan., Lee WY; Division of Thoracic Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, National Defense Medical University, Kaohsiung 80284, Taiwan.; Institute of Aquatic Science and Technology, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan., Wang CY; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan., Lee YK; School of Medicine, National Defense Medical University, Taipei 11490, Taiwan.; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, National Defense Medical University, Kaohsiung 80284, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan., Nguyen NUN; Center for Regenerative Medicine, University of South Florida Health Heart Institute, Tampa, FL 33602, USA.; Division of Cardiology, Department of Internal Medicine, Morsani School of Medicine, University of South Florida, Tampa, FL 33602, USA.
Source: International journal of medical sciences [Int J Med Sci] 2026 Mar 09; Vol. 23 (4), pp. 1408-1430. Date of Electronic Publication: 2026 Mar 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
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  Data: Integrative Multi-Omics and Single-Cell Analysis Reveal THOC3 and THOC7 as Oncogenic RNA Processing Regulators in Lung Adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences Himachal Pradesh 173229, India.<br /><searchLink fieldCode="AU" term="%22Wu+CC%22">Wu CC</searchLink>; Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Solomon+DD%22">Solomon DD</searchLink>; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Yogananda School of AI Computers and Data Sciences, Shoolini University Solan 173229, India.<br /><searchLink fieldCode="AU" term="%22Yen+MC%22">Yen MC</searchLink>; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+IJ%22">Yeh IJ</searchLink>; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ko+CC%22">Ko CC</searchLink>; Department of Medical Imaging, Chi-Mei Medical Center, Tainan 710402, Taiwan.; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Xuan+DTM%22">Xuan DTM</searchLink>; Van Lang University, 69/68 Dang Thuy Tram Street, Binh Loi Trung Ward, Ho Chi Minh City, Vietnam.<br /><searchLink fieldCode="AU" term="%22Chang+KF%22">Chang KF</searchLink>; School of Medicine, National Defense Medical University, Taipei 11490, Taiwan.; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, National Defense Medical University, Kaohsiung 80284, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HR%22">Lin HR</searchLink>; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Nursing Department, Kaohsiung Armed Forces General Hospital, National Defense Medical University, Kaohsiung, 80284, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HY%22">Lin HY</searchLink>; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.; Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan.; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA.<br /><searchLink fieldCode="AU" term="%22Shih+CL%22">Shih CL</searchLink>; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JB%22">Chen JB</searchLink>; Department of Radiology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+WY%22">Lee WY</searchLink>; Division of Thoracic Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, National Defense Medical University, Kaohsiung 80284, Taiwan.; Institute of Aquatic Science and Technology, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+CY%22">Wang CY</searchLink>; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YK%22">Lee YK</searchLink>; School of Medicine, National Defense Medical University, Taipei 11490, Taiwan.; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, National Defense Medical University, Kaohsiung 80284, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan.<br /><searchLink fieldCode="AU" term="%22Nguyen+NUN%22">Nguyen NUN</searchLink>; Center for Regenerative Medicine, University of South Florida Health Heart Institute, Tampa, FL 33602, USA.; Division of Cardiology, Department of Internal Medicine, Morsani School of Medicine, University of South Florida, Tampa, FL 33602, USA.
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