Targeted therapies in non-small cell lung cancer and their cardiovascular impact: mechanisms, clinical profiles, and strategies of management.

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Title: Targeted therapies in non-small cell lung cancer and their cardiovascular impact: mechanisms, clinical profiles, and strategies of management.
Authors: Nardin S; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.; Department of Internal Medicine and Medical Sciences (DiMI), School of Medicine, University of Genova, Genova, Italy., Vezzoli F; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Cognolato G; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Mollace R; Cardiology Unit, Humanitas Gavazzeni, Bergamo, Italy.; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy., Ramella Pollone B; Department of Internal Medicine and Medical Sciences (DiMI), School of Medicine, University of Genova, Genova, Italy.; U.O. Clinica di Oncologia Medica, IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy., Biello F; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy., Cao D; Cardiology Unit, Humanitas Gavazzeni, Bergamo, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Tagliamento M; Department of Internal Medicine and Medical Sciences (DiMI), School of Medicine, University of Genova, Genova, Italy.; U.O. Clinica di Oncologia Medica, IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy., Sarocchi M; Cardiovascular Disease Unit, IRCCS San Martino Policlinic Hospital, Genova, Italy., Pagnesi M; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Institute of Cardiology, ASST Spedali Civili, University of Brescia, Brescia, Italy., Verdoia M; Division of Cardiology, Nuovo Ospedale degli Infermi, ASL Biella, Biella, Italy., Conte B; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Grisanti S; Medical Oncology Unit, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Genova C; Department of Internal Medicine and Medical Sciences (DiMI), School of Medicine, University of Genova, Genova, Italy.; U.O. Clinica di Oncologia Medica, IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy., Gennari A; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Nardin M; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Internal Medicine, Department of Medicine, ASST Spedali Civili di Brescia, Brescia, Italy.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Mar 19; Vol. 17, pp. 1790897. Date of Electronic Publication: 2026 Mar 19 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Nardin+S%22">Nardin S</searchLink>; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.; Department of Internal Medicine and Medical Sciences (DiMI), School of Medicine, University of Genova, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Vezzoli+F%22">Vezzoli F</searchLink>; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Cognolato+G%22">Cognolato G</searchLink>; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Mollace+R%22">Mollace R</searchLink>; Cardiology Unit, Humanitas Gavazzeni, Bergamo, Italy.; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ramella+Pollone+B%22">Ramella Pollone B</searchLink>; Department of Internal Medicine and Medical Sciences (DiMI), School of Medicine, University of Genova, Genova, Italy.; U.O. Clinica di Oncologia Medica, IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Biello+F%22">Biello F</searchLink>; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Cao+D%22">Cao D</searchLink>; Cardiology Unit, Humanitas Gavazzeni, Bergamo, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tagliamento+M%22">Tagliamento M</searchLink>; Department of Internal Medicine and Medical Sciences (DiMI), School of Medicine, University of Genova, Genova, Italy.; U.O. Clinica di Oncologia Medica, IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Sarocchi+M%22">Sarocchi M</searchLink>; Cardiovascular Disease Unit, IRCCS San Martino Policlinic Hospital, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Pagnesi+M%22">Pagnesi M</searchLink>; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Institute of Cardiology, ASST Spedali Civili, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Verdoia+M%22">Verdoia M</searchLink>; Division of Cardiology, Nuovo Ospedale degli Infermi, ASL Biella, Biella, Italy.<br /><searchLink fieldCode="AU" term="%22Conte+B%22">Conte B</searchLink>; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Grisanti+S%22">Grisanti S</searchLink>; Medical Oncology Unit, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Genova+C%22">Genova C</searchLink>; Department of Internal Medicine and Medical Sciences (DiMI), School of Medicine, University of Genova, Genova, Italy.; U.O. Clinica di Oncologia Medica, IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Gennari+A%22">Gennari A</searchLink>; Division of Medical Oncology, Maggiore University Hospital, Novara, Italy.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Nardin+M%22">Nardin M</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Internal Medicine, Department of Medicine, ASST Spedali Civili di Brescia, Brescia, Italy.
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