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Multifunctional RNA G-Quadruplex Ligand for Integrated Photodynamic Therapy and Oncoprotein Translation Inhibition in Cancer Cells.

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Title: Multifunctional RNA G-Quadruplex Ligand for Integrated Photodynamic Therapy and Oncoprotein Translation Inhibition in Cancer Cells.
Authors: Long W; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, China., Zheng BX; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China., Wang YK; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China., She MT; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China., Zeng YX; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China., Zheng YY; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China., Zheng WD; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China., Zhang KX; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China., Lin DM; Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Material Science and Engineering, Shenzhen University, Shenzhen 518060, China., Mao Y; Department of Chemistry, Lakehead University and Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, Ontario P7B 6V4, Canada., Hou J; Department of Chemistry, Lakehead University and Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, Ontario P7B 6V4, Canada., Wong WL; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, China.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9284-9301. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multifunctional RNA G-Quadruplex Ligand for Integrated Photodynamic Therapy and Oncoprotein Translation Inhibition in Cancer Cells.
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  Data: <searchLink fieldCode="AU" term="%22Long+W%22">Long W</searchLink>; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, China.<br /><searchLink fieldCode="AU" term="%22Zheng+BX%22">Zheng BX</searchLink>; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.<br /><searchLink fieldCode="AU" term="%22Wang+YK%22">Wang YK</searchLink>; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.<br /><searchLink fieldCode="AU" term="%22She+MT%22">She MT</searchLink>; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.<br /><searchLink fieldCode="AU" term="%22Zeng+YX%22">Zeng YX</searchLink>; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.<br /><searchLink fieldCode="AU" term="%22Zheng+YY%22">Zheng YY</searchLink>; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.<br /><searchLink fieldCode="AU" term="%22Zheng+WD%22">Zheng WD</searchLink>; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.<br /><searchLink fieldCode="AU" term="%22Zhang+KX%22">Zhang KX</searchLink>; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.<br /><searchLink fieldCode="AU" term="%22Lin+DM%22">Lin DM</searchLink>; Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Material Science and Engineering, Shenzhen University, Shenzhen 518060, China.<br /><searchLink fieldCode="AU" term="%22Mao+Y%22">Mao Y</searchLink>; Department of Chemistry, Lakehead University and Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, Ontario P7B 6V4, Canada.<br /><searchLink fieldCode="AU" term="%22Hou+J%22">Hou J</searchLink>; Department of Chemistry, Lakehead University and Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, Ontario P7B 6V4, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+WL%22">Wong WL</searchLink>; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China.; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, China.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9284-9301. <i>Date of Electronic Publication: </i>2026 Apr 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.5c03769
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              Text: 2026 Apr 23
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