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Dynamics of the microbiota in patients with Clostridioides difficile: Recurrence, treatment, sex, and immunosuppression.

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Title: Dynamics of the microbiota in patients with Clostridioides difficile: Recurrence, treatment, sex, and immunosuppression.
Authors: Ventero MP; Microbiology Service, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain., Herrero R; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain., Tyshkovska I; Microbiology Service, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain., Valverde-Fredet MD; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain., Rodríguez JC; Microbiology Service, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.; Clinical Medicine Department, Miguel Hernández University, Elche, Spain., Rodríguez-Fernández M; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain., González-De-La-Aleja P; Unit of Infectious Diseases, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain., Trigo M; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain., Parra M; Microbiology Service, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain., Aller AI; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain., Otero S; Unit of Infectious Diseases, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain., Espindola-Gomez R; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain., Ramos JM; Clinical Medicine Department, Miguel Hernández University, Elche, Spain.; Unit of Infectious Diseases, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain., León EM; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain., García M; Unit of Infectious Diseases, Vega Baja University Hospital - Orihuela, Spain-FISABIO, Foundation for the Promotion of Health and Biomedical Research of the Valencian Community, Valencia, Spain., Navarrete-Lorite MN; Unit of Infectious Diseases, Virgen Macarena University Hospital, Sevilla, Spain., Llenas-García J; Clinical Medicine Department, Miguel Hernández University, Elche, Spain.; Unit of Infectious Diseases, Vega Baja University Hospital - Orihuela, Spain-FISABIO, Foundation for the Promotion of Health and Biomedical Research of the Valencian Community, Valencia, Spain.; CIBERINFEC, Carlos III Health Institute, Madrid, Spain., Portillo I; Unit of Infectious Diseases, Virgen Macarena University Hospital, Sevilla, Spain., Jover F; Unit of Infectious Diseases, Sant Joan D'Alacant University Hospital, Sant Joan D'Alacant, Spain., Tasias M; Infectious Diseases Service, La Fe University and Polytechnic Hospital, Valencia, Spain., Caston JJ; Unit of Infectious Diseases, Reina Sofía University Hospital, Córdoba, Spain., Gil C; Unit of Infectious Diseases, Marina Baixa Hospital, VillaJoiosa, Spain., Vinuesa-Garcia D; Unit of Infectious Diseases, San Cecilio University Hospital, Granada, Spain., Gomez-Ayerbe C; Unit of Infectious Diseases, Virgen de la Victoria University Hospital, Malaga, Spain., Martínez Marcos FJ; Unit of Infectious Diseases, Juan Ramón Jimenez University Hospital, Huelva, Spain., Merchante N; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.; Clinical Medicine Department, Miguel Hernández University, Elche, Spain., De Lucas EM; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.; Clinical Medicine Department, Miguel Hernández University, Elche, Spain.
Source: PLoS pathogens [PLoS Pathog] 2026 Apr 06; Vol. 22 (4), pp. e1014063. Date of Electronic Publication: 2026 Apr 06 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
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  Data: Dynamics of the microbiota in patients with Clostridioides difficile: Recurrence, treatment, sex, and immunosuppression.
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  Data: <searchLink fieldCode="AU" term="%22Ventero+MP%22">Ventero MP</searchLink>; Microbiology Service, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Herrero+R%22">Herrero R</searchLink>; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Tyshkovska+I%22">Tyshkovska I</searchLink>; Microbiology Service, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Valverde-Fredet+MD%22">Valverde-Fredet MD</searchLink>; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez+JC%22">Rodríguez JC</searchLink>; Microbiology Service, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.; Clinical Medicine Department, Miguel Hernández University, Elche, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Fernández+M%22">Rodríguez-Fernández M</searchLink>; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22González-De-La-Aleja+P%22">González-De-La-Aleja P</searchLink>; Unit of Infectious Diseases, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Trigo+M%22">Trigo M</searchLink>; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Parra+M%22">Parra M</searchLink>; Microbiology Service, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Aller+AI%22">Aller AI</searchLink>; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Otero+S%22">Otero S</searchLink>; Unit of Infectious Diseases, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Espindola-Gomez+R%22">Espindola-Gomez R</searchLink>; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Ramos+JM%22">Ramos JM</searchLink>; Clinical Medicine Department, Miguel Hernández University, Elche, Spain.; Unit of Infectious Diseases, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22León+EM%22">León EM</searchLink>; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22García+M%22">García M</searchLink>; Unit of Infectious Diseases, Vega Baja University Hospital - Orihuela, Spain-FISABIO, Foundation for the Promotion of Health and Biomedical Research of the Valencian Community, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Navarrete-Lorite+MN%22">Navarrete-Lorite MN</searchLink>; Unit of Infectious Diseases, Virgen Macarena University Hospital, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Llenas-García+J%22">Llenas-García J</searchLink>; Clinical Medicine Department, Miguel Hernández University, Elche, Spain.; Unit of Infectious Diseases, Vega Baja University Hospital - Orihuela, Spain-FISABIO, Foundation for the Promotion of Health and Biomedical Research of the Valencian Community, Valencia, Spain.; CIBERINFEC, Carlos III Health Institute, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Portillo+I%22">Portillo I</searchLink>; Unit of Infectious Diseases, Virgen Macarena University Hospital, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Jover+F%22">Jover F</searchLink>; Unit of Infectious Diseases, Sant Joan D'Alacant University Hospital, Sant Joan D'Alacant, Spain.<br /><searchLink fieldCode="AU" term="%22Tasias+M%22">Tasias M</searchLink>; Infectious Diseases Service, La Fe University and Polytechnic Hospital, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Caston+JJ%22">Caston JJ</searchLink>; Unit of Infectious Diseases, Reina Sofía University Hospital, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Gil+C%22">Gil C</searchLink>; Unit of Infectious Diseases, Marina Baixa Hospital, VillaJoiosa, Spain.<br /><searchLink fieldCode="AU" term="%22Vinuesa-Garcia+D%22">Vinuesa-Garcia D</searchLink>; Unit of Infectious Diseases, San Cecilio University Hospital, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Gomez-Ayerbe+C%22">Gomez-Ayerbe C</searchLink>; Unit of Infectious Diseases, Virgen de la Victoria University Hospital, Malaga, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez+Marcos+FJ%22">Martínez Marcos FJ</searchLink>; Unit of Infectious Diseases, Juan Ramón Jimenez University Hospital, Huelva, Spain.<br /><searchLink fieldCode="AU" term="%22Merchante+N%22">Merchante N</searchLink>; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.; Clinical Medicine Department, Miguel Hernández University, Elche, Spain.<br /><searchLink fieldCode="AU" term="%22De+Lucas+EM%22">De Lucas EM</searchLink>; Clinical Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Seville (IBiS), University of Seville, Sevilla, Spain.; Clinical Medicine Department, Miguel Hernández University, Elche, Spain.
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