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Advanced microfluidic and 3D cell culture platforms for modeling vascularization in diabetic foot ulcers: A systematic review of translational challenges and perspectives.

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Title: Advanced microfluidic and 3D cell culture platforms for modeling vascularization in diabetic foot ulcers: A systematic review of translational challenges and perspectives.
Authors: da Silva AKA; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil., Nunes GAMA; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil., Faria RM; Federal Institute of Education, Science and Technology of Triângulo Mineiro - IFTM, Campus Paracatu, Department of Electrical Engineering, Paracatu, Minas Gerais, Brazil., Santos K; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil.; Federal Institute of Education, Science and Technology of Triângulo Mineiro - IFTM, Campus Paracatu, Department of Electrical Engineering, Paracatu, Minas Gerais, Brazil., Pissinati de Souza R; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil.; Federal Institute of Education, Science and Technology of Rondônia, Porto Velho, Rondônia, Brazil., da Costa LBM; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil., Fonseca MAM; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil., Fortes SSG; University of São Paulo - USP, Institute of Chemistry of São Carlos, Department of Chemistry and Molecular Physics, São Carlos, São Paulo, Brazil., Lima AM; University of São Paulo - USP, Institute of Chemistry of São Carlos, Department of Chemistry and Molecular Physics, São Carlos, São Paulo, Brazil., Monteiro I; University of São Paulo - USP, Institute of the Sea, Department of Bioproducts and Bioprocesses, Santos, São Paulo, Brazil., Almeida PH; Federal University of Ceará - UFC, Physical Therapist, Center for Research and Technological Innovations in Human Rehabilitation - INOVAFISIO, Fortaleza, Ceará, Brazil., Figueira ACM; National Center for Research in Energy and Materials - CNPEM, National Laboratory of Biosciences - LNBIO, Campinas, São Paulo, Brazil., Santana HS; Renato Archer Information Technology Center, Campinas, São Paulo, Brazil., Carneiro MLB; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil.; University of Brasilia - UnB, Campus Ceilândia, Postgraduate Program in Nanoscience and Nanobiotechnology and Postgraduate Program in Health Sciences and Technologies, Ceilândia, Distrito Federal, Brazil., da Silva Luz GV; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil., Joanitti G; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil.; University of Brasilia - UnB, Campus Ceilândia, Postgraduate Program in Nanoscience and Nanobiotechnology and Postgraduate Program in Health Sciences and Technologies, Ceilândia, Distrito Federal, Brazil., Tatmatsu-Rocha JC; Federal University of Ceará - UFC, Physical Therapist, Center for Research and Technological Innovations in Human Rehabilitation - INOVAFISIO, Fortaleza, Ceará, Brazil.; Federal University of Ceara - UFC, Medicine School, Postgraduate Programs in Biomedical Engineering and in Physiotherapy and Functionality, Fortaleza, Ceara, Brazil., Rosa MFF; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil., Martins MA; Nanotechnology National Laboratory for Agriculture, Embrapa Instrumentation, São Carlos, São Paulo, Brazil., Santos Í; University of Wisconsin-Madison, Department of Biomedical Engineering, Madison, Wisconsin, United States of America., Carrilho E; University of São Paulo - USP, Institute of Chemistry of São Carlos, Department of Chemistry and Molecular Physics, São Carlos, São Paulo, Brazil.; National Institute of Science and Technology in Bioanalytics - Lauro Kubota, Campinas, São Paulo, Brazil., da Rocha AF; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil., Fleury Rosa SSR; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil.; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil.; Meinig School of Biomedical Engineering, Master of engineering (M.Eng.) Program, Cornell University, Ithaca, New York, United States of America.
Source: PloS one [PLoS One] 2026 Apr 06; Vol. 21 (4), pp. e0328278. Date of Electronic Publication: 2026 Apr 06 (Print Publication: 2026).
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Advanced microfluidic and 3D cell culture platforms for modeling vascularization in diabetic foot ulcers: A systematic review of translational challenges and perspectives.
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  Data: <searchLink fieldCode="AU" term="%22da+Silva+AKA%22">da Silva AKA</searchLink>; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil.<br /><searchLink fieldCode="AU" term="%22Nunes+GAMA%22">Nunes GAMA</searchLink>; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil.<br /><searchLink fieldCode="AU" term="%22Faria+RM%22">Faria RM</searchLink>; Federal Institute of Education, Science and Technology of Triângulo Mineiro - IFTM, Campus Paracatu, Department of Electrical Engineering, Paracatu, Minas Gerais, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos+K%22">Santos K</searchLink>; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil.; Federal Institute of Education, Science and Technology of Triângulo Mineiro - IFTM, Campus Paracatu, Department of Electrical Engineering, Paracatu, Minas Gerais, Brazil.<br /><searchLink fieldCode="AU" term="%22Pissinati+de+Souza+R%22">Pissinati de Souza R</searchLink>; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil.; Federal Institute of Education, Science and Technology of Rondônia, Porto Velho, Rondônia, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Costa+LBM%22">da Costa LBM</searchLink>; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil.<br /><searchLink fieldCode="AU" term="%22Fonseca+MAM%22">Fonseca MAM</searchLink>; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil.<br /><searchLink fieldCode="AU" term="%22Fortes+SSG%22">Fortes SSG</searchLink>; University of São Paulo - USP, Institute of Chemistry of São Carlos, Department of Chemistry and Molecular Physics, São Carlos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Lima+AM%22">Lima AM</searchLink>; University of São Paulo - USP, Institute of Chemistry of São Carlos, Department of Chemistry and Molecular Physics, São Carlos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Monteiro+I%22">Monteiro I</searchLink>; University of São Paulo - USP, Institute of the Sea, Department of Bioproducts and Bioprocesses, Santos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Almeida+PH%22">Almeida PH</searchLink>; Federal University of Ceará - UFC, Physical Therapist, Center for Research and Technological Innovations in Human Rehabilitation - INOVAFISIO, Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22Figueira+ACM%22">Figueira ACM</searchLink>; National Center for Research in Energy and Materials - CNPEM, National Laboratory of Biosciences - LNBIO, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Santana+HS%22">Santana HS</searchLink>; Renato Archer Information Technology Center, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Carneiro+MLB%22">Carneiro MLB</searchLink>; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil.; University of Brasilia - UnB, Campus Ceilândia, Postgraduate Program in Nanoscience and Nanobiotechnology and Postgraduate Program in Health Sciences and Technologies, Ceilândia, Distrito Federal, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Luz+GV%22">da Silva Luz GV</searchLink>; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil.<br /><searchLink fieldCode="AU" term="%22Joanitti+G%22">Joanitti G</searchLink>; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil.; University of Brasilia - UnB, Campus Ceilândia, Postgraduate Program in Nanoscience and Nanobiotechnology and Postgraduate Program in Health Sciences and Technologies, Ceilândia, Distrito Federal, Brazil.<br /><searchLink fieldCode="AU" term="%22Tatmatsu-Rocha+JC%22">Tatmatsu-Rocha JC</searchLink>; Federal University of Ceará - UFC, Physical Therapist, Center for Research and Technological Innovations in Human Rehabilitation - INOVAFISIO, Fortaleza, Ceará, Brazil.; Federal University of Ceara - UFC, Medicine School, Postgraduate Programs in Biomedical Engineering and in Physiotherapy and Functionality, Fortaleza, Ceara, Brazil.<br /><searchLink fieldCode="AU" term="%22Rosa+MFF%22">Rosa MFF</searchLink>; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil.<br /><searchLink fieldCode="AU" term="%22Martins+MA%22">Martins MA</searchLink>; Nanotechnology National Laboratory for Agriculture, Embrapa Instrumentation, São Carlos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos+Í%22">Santos Í</searchLink>; University of Wisconsin-Madison, Department of Biomedical Engineering, Madison, Wisconsin, United States of America.<br /><searchLink fieldCode="AU" term="%22Carrilho+E%22">Carrilho E</searchLink>; University of São Paulo - USP, Institute of Chemistry of São Carlos, Department of Chemistry and Molecular Physics, São Carlos, São Paulo, Brazil.; National Institute of Science and Technology in Bioanalytics - Lauro Kubota, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Rocha+AF%22">da Rocha AF</searchLink>; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil.<br /><searchLink fieldCode="AU" term="%22Fleury+Rosa+SSR%22">Fleury Rosa SSR</searchLink>; University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil.; University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil.; Meinig School of Biomedical Engineering, Master of engineering (M.Eng.) Program, Cornell University, Ithaca, New York, United States of America.
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