Effects of Protective Ventilation with Lung Expansion versus Permissive Atelectasis on Pulmonary Inflammation and Mechanical Power of Ventilation in an Experimental Model of Acute Lung Injury.

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Title: Effects of Protective Ventilation with Lung Expansion versus Permissive Atelectasis on Pulmonary Inflammation and Mechanical Power of Ventilation in an Experimental Model of Acute Lung Injury.
Authors: Scharffenberg M; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Huhle R; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Braune A; Department of Nuclear Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Dresden, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Positron Emission Tomography, Germany; Medizinische Fakultät and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany., Ran X; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department of Intensive Care, Chongqing General Hospital, University of Chinese Academy of Science, Chongqing, China., Zhang Y; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department of Anesthesiology, Affiliated Hospital of Southwest Medical University, Luzhou, China., Theilen R; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Maiello L; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Anesthesia and Critical Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy., Benzi G; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Service of Anesthesia and Intensive Care, Department of Clinical and Biological Sciences 'Ospedale di Circolo e Fondazione Macchi,' University of Insubria, Varese, Italy., Schultz MJ; Department of Intensive Care and Laboratory of Experimental Intensive Care and Anaesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Rocco PRM; Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Brazil., Neto AS; Department of Critical Care Medicine, Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, Melbourne, Australia., Koch T; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Kotzerke J; Department of Nuclear Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Dresden, Germany., Wittenstein J; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Gama de Abreu M; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, Medical University Graz, Austria; Department of Intensive Care and Resuscitation, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio; Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio.
Source: Anesthesiology [Anesthesiology] 2026 Jul 01; Vol. 145 (1), pp. 84-97. Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1300217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1175 (Electronic) Linking ISSN: 00033022 NLM ISO Abbreviation: Anesthesiology Subsets: MEDLINE
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  Data: Effects of Protective Ventilation with Lung Expansion versus Permissive Atelectasis on Pulmonary Inflammation and Mechanical Power of Ventilation in an Experimental Model of Acute Lung Injury.
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  Data: <searchLink fieldCode="AU" term="%22Scharffenberg+M%22">Scharffenberg M</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Huhle+R%22">Huhle R</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Braune+A%22">Braune A</searchLink>; Department of Nuclear Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Dresden, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Positron Emission Tomography, Germany; Medizinische Fakultät and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ran+X%22">Ran X</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department of Intensive Care, Chongqing General Hospital, University of Chinese Academy of Science, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department of Anesthesiology, Affiliated Hospital of Southwest Medical University, Luzhou, China.<br /><searchLink fieldCode="AU" term="%22Theilen+R%22">Theilen R</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Maiello+L%22">Maiello L</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Anesthesia and Critical Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Benzi+G%22">Benzi G</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Service of Anesthesia and Intensive Care, Department of Clinical and Biological Sciences 'Ospedale di Circolo e Fondazione Macchi,' University of Insubria, Varese, Italy.<br /><searchLink fieldCode="AU" term="%22Schultz+MJ%22">Schultz MJ</searchLink>; Department of Intensive Care and Laboratory of Experimental Intensive Care and Anaesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rocco+PRM%22">Rocco PRM</searchLink>; Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Neto+AS%22">Neto AS</searchLink>; Department of Critical Care Medicine, Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Koch+T%22">Koch T</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Kotzerke+J%22">Kotzerke J</searchLink>; Department of Nuclear Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Wittenstein+J%22">Wittenstein J</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Gama+de+Abreu+M%22">Gama de Abreu M</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, Medical University Graz, Austria; Department of Intensive Care and Resuscitation, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio; Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio.
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  Data: <searchLink fieldCode="JN" term="%221300217%22">Anesthesiology</searchLink> [Anesthesiology] 2026 Jul 01; Vol. 145 (1), pp. 84-97. <i>Date of Electronic Publication: </i>2026 Apr 03.
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