Cooperative engineering of distal and proximal domains in L-alanine dehydrogenase breaks activity-stability trade-off for efficient hydroxypyruvic acid synthesis.
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| Title: | Cooperative engineering of distal and proximal domains in L-alanine dehydrogenase breaks activity-stability trade-off for efficient hydroxypyruvic acid synthesis. |
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| Authors: | Wang C; Department of Biological Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China., Miao J; Department of Biological Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China., Chen Q; Department of Biological Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China., Wang H; Department of Biological Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China., Guo Y; Department of Biological Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China., Sun H; Department of Biological Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China., Chang Y; Department of Environmental Science and Engineering, School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing, 100083, China; Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, Beijing, 100083, China., Luo H; Department of Biological Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China. Electronic address: luohui@ustb.edu.cn. |
| Source: | International journal of biological macromolecules [Int J Biol Macromol] 2026 Apr; Vol. 359, pp. 151855. Date of Electronic Publication: 2026 Apr 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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