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Structural and mechanistic basis for antibody neutralization of the measles fusion protein.

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Title: Structural and mechanistic basis for antibody neutralization of the measles fusion protein.
Authors: Zyla DS; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Della Marca R; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of General and Specialized Surgery for Women and Children, University of Campania 'Luigi Vanvitelli', Naples, Italy., Lacarbonara D; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Niemeyer G; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Zipursky G; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Di Clemente L; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of General and Specialized Surgery for Women and Children, University of Campania 'Luigi Vanvitelli', Naples, Italy., Verbruggen MHL; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands., van Dijk LLA; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands., Ceh OM; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Instituto Politécnico Nacional (IPN), Mexico City, Mexico., Jonathan-Trakht G; Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Kalantarov G; Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Acciani M; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Laterza G; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; One-Health Unit, Department of Biomedical, Surgical and Dental Science, School of Medicine, University of Milan, Milan, Italy., Vyshenska D; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Leedale C; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA., Pawlack E; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA., Hastie KM; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Horvat B; Immunobiology of Viral Infections, CIRI, International Center for Infectiology Research, INSERM U1111, CNRS UMR5308, University Lyon 1, ENS de Lyon, Lyon, France., de Swart RL; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands., de Vries RD; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands., Greninger AL; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Niewiesk S; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA., Ollmann Saphire E; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA. erica@lji.org.; Department of Medicine, University of California San Diego, La Jolla, CA, USA. erica@lji.org., Porotto M; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. mp3509@columbia.edu.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. mp3509@columbia.edu.; Department of General and Specialized Surgery for Women and Children, University of Campania 'Luigi Vanvitelli', Naples, Italy. mp3509@columbia.edu.
Source: Nature communications [Nat Commun] 2026 Apr 06; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural and mechanistic basis for antibody neutralization of the measles fusion protein.
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  Data: <searchLink fieldCode="AU" term="%22Zyla+DS%22">Zyla DS</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Della+Marca+R%22">Della Marca R</searchLink>; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of General and Specialized Surgery for Women and Children, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Lacarbonara+D%22">Lacarbonara D</searchLink>; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Niemeyer+G%22">Niemeyer G</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zipursky+G%22">Zipursky G</searchLink>; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Di+Clemente+L%22">Di Clemente L</searchLink>; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of General and Specialized Surgery for Women and Children, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Verbruggen+MHL%22">Verbruggen MHL</searchLink>; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Dijk+LLA%22">van Dijk LLA</searchLink>; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ceh+OM%22">Ceh OM</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Instituto Politécnico Nacional (IPN), Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Jonathan-Trakht+G%22">Jonathan-Trakht G</searchLink>; Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kalantarov+G%22">Kalantarov G</searchLink>; Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Acciani+M%22">Acciani M</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Laterza+G%22">Laterza G</searchLink>; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; One-Health Unit, Department of Biomedical, Surgical and Dental Science, School of Medicine, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Vyshenska+D%22">Vyshenska D</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Leedale+C%22">Leedale C</searchLink>; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Pawlack+E%22">Pawlack E</searchLink>; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hastie+KM%22">Hastie KM</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Horvat+B%22">Horvat B</searchLink>; Immunobiology of Viral Infections, CIRI, International Center for Infectiology Research, INSERM U1111, CNRS UMR5308, University Lyon 1, ENS de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22de+Swart+RL%22">de Swart RL</searchLink>; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Vries+RD%22">de Vries RD</searchLink>; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Greninger+AL%22">Greninger AL</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Niewiesk+S%22">Niewiesk S</searchLink>; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ollmann+Saphire+E%22">Ollmann Saphire E</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA. erica@lji.org.; Department of Medicine, University of California San Diego, La Jolla, CA, USA. erica@lji.org.<br /><searchLink fieldCode="AU" term="%22Porotto+M%22">Porotto M</searchLink>; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. mp3509@columbia.edu.; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. mp3509@columbia.edu.; Department of General and Specialized Surgery for Women and Children, University of Campania 'Luigi Vanvitelli', Naples, Italy. mp3509@columbia.edu.
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