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The E3 ubiquitin ligase HUWE1 is required for KRAS-induced lung cancer.

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Title: The E3 ubiquitin ligase HUWE1 is required for KRAS-induced lung cancer.
Authors: Searle J; Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. Joshua.searle@ucl.ac.uk.; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK. Joshua.searle@ucl.ac.uk.; Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London (UCL), London, UK. Joshua.searle@ucl.ac.uk., Menotti M; Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK., McDaid WJ; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Baker MJ; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Chaturvedi A; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK., Ginn L; Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK., Reed H; Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK., Carter M; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK., Blackhall F; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK., Lindsay CR; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK., Malliri A; Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. angeliki.malliri@manchester.ac.uk.; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK. angeliki.malliri@manchester.ac.uk.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. angeliki.malliri@manchester.ac.uk.
Source: Cell death & disease [Cell Death Dis] 2026 Apr 07; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The E3 ubiquitin ligase HUWE1 is required for KRAS-induced lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Searle+J%22">Searle J</searchLink>; Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. Joshua.searle@ucl.ac.uk.; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK. Joshua.searle@ucl.ac.uk.; Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London (UCL), London, UK. Joshua.searle@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Menotti+M%22">Menotti M</searchLink>; Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22McDaid+WJ%22">McDaid WJ</searchLink>; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Baker+MJ%22">Baker MJ</searchLink>; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Chaturvedi+A%22">Chaturvedi A</searchLink>; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Ginn+L%22">Ginn L</searchLink>; Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Reed+H%22">Reed H</searchLink>; Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Carter+M%22">Carter M</searchLink>; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Blackhall+F%22">Blackhall F</searchLink>; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Lindsay+CR%22">Lindsay CR</searchLink>; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Malliri+A%22">Malliri A</searchLink>; Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. angeliki.malliri@manchester.ac.uk.; Cancer Research UK Lung Cancer Centre of Excellence, The University of Manchester, Manchester, UK. angeliki.malliri@manchester.ac.uk.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. angeliki.malliri@manchester.ac.uk.
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