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Isatuximab, carfilzomib, lenalidomide and dexamethasone in newly diagnosed multiple myeloma: a randomized phase 3 trial.

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Title: Isatuximab, carfilzomib, lenalidomide and dexamethasone in newly diagnosed multiple myeloma: a randomized phase 3 trial.
Authors: Gay F; Division of Hematology, AOU Città della Salute e della Scienza di Torino, University of Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy. francesca.gay@unito.it., Roeloffzen W; Department of Hematology, University Medical Center Groningen, Groningen, the Netherlands., Dimopoulos MA; Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.; Department of Medicine, Korea University, Seoul, South Korea., Rosiñol L; Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clínic de Barcelona, IDIBAPS, and PETHEMA/GEM, Barcelona, Spain., van der Klift M; Department of Internal Medicine, Amphia Hospital, Breda, the Netherlands., Mina R; Division of Hematology, AOU Città della Salute e della Scienza di Torino, University of Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy., Oriol A; Institut Català d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Badalona, Spain., Katodritou E; Department of Hematology, Theagenion Cancer Hospital, Thessaloniki, Greece., Wu KL; ZAS Cadix, Antwerp, Belgium., Rodríguez Otero P; Cancer Center Clínica Universidad de Navarra, Pamplona, Spain., Hájek R; Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic., Antonioli E; Hematology Unit, AOU Careggi, Florence, Italy., van Duin M; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., D'Agostino M; Division of Hematology, AOU Città della Salute e della Scienza di Torino, University of Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy., Martínez-López J; Hematology Department, Hospital Universitario de Octubre, Medicine Department Complutense University, imas12, CNIO, Madrid, Spain., van Leeuwen-Segarceanu EM; Department of Hematology, St. Antonius Hospital, Nieuwegein, the Netherlands., Zamagni E; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Bologna, Italy.; Department of Medical and Surgical Sciences, Bologna University School of Medicine, Bologna, Italy., van de Donk NWCJ; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, Amsterdam, the Netherlands., Weisel KC; Department of Oncology, Hematology and BMT, University Medical Center of Hamburg-Eppendorf, Hamburg, Germany., Pour L; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic., Radocha J; 4th Department of Internal Medicine-Hematology, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic., Belotti A; Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy., Schjesvold F; Oslo Myeloma Center, Department of Hematology, Oslo University Hospital, Oslo, Norway.; KG Jebsen Center for B cell malignancies, University of Oslo, Oslo, Norway., Bladé J; Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clínic de Barcelona, IDIBAPS, and PETHEMA/GEM, Barcelona, Spain., Einsele H; Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany., Sonneveld P; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.; European Myeloma Network (EMN), Rotterdam, the Netherlands., Boccadoro M; European Myeloma Network (EMN), Turin, Italy., Broijl A; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Source: Nature medicine [Nat Med] 2026 May; Vol. 32 (5), pp. 1773-1782. Date of Electronic Publication: 2026 Apr 06.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Isatuximab, carfilzomib, lenalidomide and dexamethasone in newly diagnosed multiple myeloma: a randomized phase 3 trial.
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  Data: <searchLink fieldCode="AU" term="%22Gay+F%22">Gay F</searchLink>; Division of Hematology, AOU Città della Salute e della Scienza di Torino, University of Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy. francesca.gay@unito.it.<br /><searchLink fieldCode="AU" term="%22Roeloffzen+W%22">Roeloffzen W</searchLink>; Department of Hematology, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dimopoulos+MA%22">Dimopoulos MA</searchLink>; Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.; Department of Medicine, Korea University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Rosiñol+L%22">Rosiñol L</searchLink>; Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clínic de Barcelona, IDIBAPS, and PETHEMA/GEM, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22van+der+Klift+M%22">van der Klift M</searchLink>; Department of Internal Medicine, Amphia Hospital, Breda, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mina+R%22">Mina R</searchLink>; Division of Hematology, AOU Città della Salute e della Scienza di Torino, University of Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Oriol+A%22">Oriol A</searchLink>; Institut Català d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Katodritou+E%22">Katodritou E</searchLink>; Department of Hematology, Theagenion Cancer Hospital, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Wu+KL%22">Wu KL</searchLink>; ZAS Cadix, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Rodríguez+Otero+P%22">Rodríguez Otero P</searchLink>; Cancer Center Clínica Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Hájek+R%22">Hájek R</searchLink>; Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic.; Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Antonioli+E%22">Antonioli E</searchLink>; Hematology Unit, AOU Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22van+Duin+M%22">van Duin M</searchLink>; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22D'Agostino+M%22">D'Agostino M</searchLink>; Division of Hematology, AOU Città della Salute e della Scienza di Torino, University of Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Martínez-López+J%22">Martínez-López J</searchLink>; Hematology Department, Hospital Universitario de Octubre, Medicine Department Complutense University, imas12, CNIO, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22van+Leeuwen-Segarceanu+EM%22">van Leeuwen-Segarceanu EM</searchLink>; Department of Hematology, St. Antonius Hospital, Nieuwegein, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zamagni+E%22">Zamagni E</searchLink>; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Bologna, Italy.; Department of Medical and Surgical Sciences, Bologna University School of Medicine, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22van+de+Donk+NWCJ%22">van de Donk NWCJ</searchLink>; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Weisel+KC%22">Weisel KC</searchLink>; Department of Oncology, Hematology and BMT, University Medical Center of Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Pour+L%22">Pour L</searchLink>; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Radocha+J%22">Radocha J</searchLink>; 4th Department of Internal Medicine-Hematology, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Belotti+A%22">Belotti A</searchLink>; Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Schjesvold+F%22">Schjesvold F</searchLink>; Oslo Myeloma Center, Department of Hematology, Oslo University Hospital, Oslo, Norway.; KG Jebsen Center for B cell malignancies, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Bladé+J%22">Bladé J</searchLink>; Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clínic de Barcelona, IDIBAPS, and PETHEMA/GEM, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Einsele+H%22">Einsele H</searchLink>; Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sonneveld+P%22">Sonneveld P</searchLink>; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.; European Myeloma Network (EMN), Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Boccadoro+M%22">Boccadoro M</searchLink>; European Myeloma Network (EMN), Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Broijl+A%22">Broijl A</searchLink>; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 May; Vol. 32 (5), pp. 1773-1782. <i>Date of Electronic Publication: </i>2026 Apr 06.
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