Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.

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Title: Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.
Authors: Kimura K; Department of Psychology, University of Wisconsin - Milwaukee, Milwaukee, WI, 53711, USA., Driscoll I; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. idriscoll@medicine.wisc.edu.; Wisconsin Alzheimer's Institute, Madison, WI, USA. idriscoll@medicine.wisc.edu., Cook N; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Shahzad S; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Betthauser TJ; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA., Johnson SC; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA., Asthana S; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA., Gallagher CL; Geriatric Research Education and Clinical Center William S. Middleton VA Hospital, Madison, WI, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health Madison, Madison, WI, USA., Hermann BP; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health Madison, Madison, WI, USA., Sager MA; Wisconsin Alzheimer's Institute, Madison, WI, USA., Blennow K; Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory Sahlgrenska University Hospital, Mölndal, Sweden.; Pitié-Salpêtrière Hospital, Paris Brain Institute, ICM, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, P.R. China., Zetterberg H; Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square London, UK.; Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Centre for Brain Research, Indian Institute of Science, Bangalore, India., Carlsson CM; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA.; Geriatric Research Education and Clinical Center William S. Middleton VA Hospital, Madison, WI, USA., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Okonkwo OC; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. ozioma@medicine.wisc.edu.; Wisconsin Alzheimer's Institute, Madison, WI, USA. ozioma@medicine.wisc.edu.
Source: Neurotoxicity research [Neurotox Res] 2026 Apr 07; Vol. 44 (2). Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 100929017 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-3524 (Electronic) Linking ISSN: 10298428 NLM ISO Abbreviation: Neurotox Res Subsets: MEDLINE
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  Data: Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.
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  Data: <searchLink fieldCode="AU" term="%22Kimura+K%22">Kimura K</searchLink>; Department of Psychology, University of Wisconsin - Milwaukee, Milwaukee, WI, 53711, USA.<br /><searchLink fieldCode="AU" term="%22Driscoll+I%22">Driscoll I</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. idriscoll@medicine.wisc.edu.; Wisconsin Alzheimer's Institute, Madison, WI, USA. idriscoll@medicine.wisc.edu.<br /><searchLink fieldCode="AU" term="%22Cook+N%22">Cook N</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Shahzad+S%22">Shahzad S</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Betthauser+TJ%22">Betthauser TJ</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+SC%22">Johnson SC</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Asthana+S%22">Asthana S</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Gallagher+CL%22">Gallagher CL</searchLink>; Geriatric Research Education and Clinical Center William S. Middleton VA Hospital, Madison, WI, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Hermann+BP%22">Hermann BP</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Sager+MA%22">Sager MA</searchLink>; Wisconsin Alzheimer's Institute, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory Sahlgrenska University Hospital, Mölndal, Sweden.; Pitié-Salpêtrière Hospital, Paris Brain Institute, ICM, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square London, UK.; Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Centre for Brain Research, Indian Institute of Science, Bangalore, India.<br /><searchLink fieldCode="AU" term="%22Carlsson+CM%22">Carlsson CM</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA.; Geriatric Research Education and Clinical Center William S. Middleton VA Hospital, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Kollmorgen+G%22">Kollmorgen G</searchLink>; Roche Diagnostics GmbH, Penzberg, Germany.<br /><searchLink fieldCode="AU" term="%22Okonkwo+OC%22">Okonkwo OC</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. ozioma@medicine.wisc.edu.; Wisconsin Alzheimer's Institute, Madison, WI, USA. ozioma@medicine.wisc.edu.
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