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Deep learning-enabled scaffolding of spatial arrays of PfCSP epitopes.

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Title: Deep learning-enabled scaffolding of spatial arrays of PfCSP epitopes.
Authors: Wu NR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037., Castro KM; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland., Beutler N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Raghavan SSR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Martin GM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Jain M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Agrawal S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Liguori A; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Kalyuzhniy O; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Skog PD; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Terada S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Lai YC; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, CA 92037., Ndihokubwayo J; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, CA 92037., Lu D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Eskandarzadeh S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Alavi N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Phelps N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Tingle R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Youhanna JE; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Amirzehni S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037., Rogers TF; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, CA 92037., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; The Ragon Institute of Mass General Brigham, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Correia BE; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland., Schief WR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; The Ragon Institute of Mass General Brigham, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139.; Moderna, Inc., Cambridge, MA 02139.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 14; Vol. 123 (15), pp. e2521914123. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wu+NR%22">Wu NR</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Castro+KM%22">Castro KM</searchLink>; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.<br /><searchLink fieldCode="AU" term="%22Beutler+N%22">Beutler N</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Lee+WH%22">Lee WH</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Raghavan+SSR%22">Raghavan SSR</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Martin+GM%22">Martin GM</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Jain+M%22">Jain M</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Agrawal+S%22">Agrawal S</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Liguori+A%22">Liguori A</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Kalyuzhniy+O%22">Kalyuzhniy O</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Skog+PD%22">Skog PD</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; 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IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Eskandarzadeh+S%22">Eskandarzadeh S</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Alavi+N%22">Alavi N</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Phelps+N%22">Phelps N</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Tingle+R%22">Tingle R</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Youhanna+JE%22">Youhanna JE</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Amirzehni+S%22">Amirzehni S</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Rogers+TF%22">Rogers TF</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, CA 92037.<br /><searchLink fieldCode="AU" term="%22Burton+DR%22">Burton DR</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; The Ragon Institute of Mass General Brigham, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Wilson+IA%22">Wilson IA</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Correia+BE%22">Correia BE</searchLink>; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schief+WR%22">Schief WR</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; The Ragon Institute of Mass General Brigham, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139.; Moderna, Inc., Cambridge, MA 02139.
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