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Hypoxia inducible factors regulate pneumovirus replication by enhancing innate immune sensing.

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Title: Hypoxia inducible factors regulate pneumovirus replication by enhancing innate immune sensing.
Authors: Ha J; CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Sharma P; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom., Ta S; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom., Tsukuda S; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom., Harris JM; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom., Penrice-Randal R; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom., Bentley E; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom., Kirby A; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom., Mega DF; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom., Matthews DA; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom., Balfe P; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom., Rehwinkel J; Medical Research Council Translational Immune Discovery Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom., Kipar A; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.; Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich 8057, Switzerland., Stewart JP; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom., McKeating JA; CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom., Wing PAC; CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 14; Vol. 123 (15), pp. e2506647123. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Hypoxia inducible factors regulate pneumovirus replication by enhancing innate immune sensing.
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  Data: <searchLink fieldCode="AU" term="%22Ha+J%22">Ha J</searchLink>; CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sharma+P%22">Sharma P</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ta+S%22">Ta S</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tsukuda+S%22">Tsukuda S</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Harris+JM%22">Harris JM</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Penrice-Randal+R%22">Penrice-Randal R</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bentley+E%22">Bentley E</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kirby+A%22">Kirby A</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mega+DF%22">Mega DF</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Matthews+DA%22">Matthews DA</searchLink>; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Balfe+P%22">Balfe P</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rehwinkel+J%22">Rehwinkel J</searchLink>; Medical Research Council Translational Immune Discovery Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kipar+A%22">Kipar A</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.; Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich 8057, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stewart+JP%22">Stewart JP</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McKeating+JA%22">McKeating JA</searchLink>; CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wing+PAC%22">Wing PAC</searchLink>; CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
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