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African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children.

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Title: African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children.
Authors: Muriuki JM; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. jmuriuki@kemri-wellcome.org., Mentzer AJ; Centre for Human Genetics, University of Oxford, Oxford, UK.; CAMS Oxford Institute, University of Oxford, Oxford, UK., Band G; Centre for Human Genetics, University of Oxford, Oxford, UK., Chong AY; Centre for Human Genetics, University of Oxford, Oxford, UK., Macharia AW; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Mogire RM; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Abuga KM; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Mitchell R; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Gilchrist JJ; Oxford Vaccine Group, University of Oxford, Oxford, UK., Webb EL; MRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK., Ndungu FM; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Ekunwe L; Department of Medicine, University of MS Medical Center, Jackson, USA., Bentley AR; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Sirima SB; Groupe de Recherche Action en Sante (GRAS), Ouagadougou, Burkina Faso., Madhi SA; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Hill AVS; Centre for Human Genetics, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Oxford, UK., Prentice AM; MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, The Gambia., Bejon P; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Modernising Medical Microbiology Unit, University of Oxford, Oxford, UK., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Sandhu MS; Department of Epidemiology & Biostatistics, Imperial College London, London, UK., Elliott AM; MRC/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK., Williams TN; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.; Department of Surgery and Cancer, Imperial College London, London, UK., Adeyemo A; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Atkinson SH; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. satkinson@kemri-wellcome.org.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. satkinson@kemri-wellcome.org.; Department of Paediatrics, University of Oxford, Oxford, UK. satkinson@kemri-wellcome.org.
Source: Nature communications [Nat Commun] 2026 Apr 07. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children.
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  Data: <searchLink fieldCode="AU" term="%22Muriuki+JM%22">Muriuki JM</searchLink>; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. jmuriuki@kemri-wellcome.org.<br /><searchLink fieldCode="AU" term="%22Mentzer+AJ%22">Mentzer AJ</searchLink>; Centre for Human Genetics, University of Oxford, Oxford, UK.; CAMS Oxford Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Band+G%22">Band G</searchLink>; Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Chong+AY%22">Chong AY</searchLink>; Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Macharia+AW%22">Macharia AW</searchLink>; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mogire+RM%22">Mogire RM</searchLink>; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Abuga+KM%22">Abuga KM</searchLink>; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mitchell+R%22">Mitchell R</searchLink>; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Gilchrist+JJ%22">Gilchrist JJ</searchLink>; Oxford Vaccine Group, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Webb+EL%22">Webb EL</searchLink>; MRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Ndungu+FM%22">Ndungu FM</searchLink>; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Raffield+LM%22">Raffield LM</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ekunwe+L%22">Ekunwe L</searchLink>; Department of Medicine, University of MS Medical Center, Jackson, USA.<br /><searchLink fieldCode="AU" term="%22Bentley+AR%22">Bentley AR</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sirima+SB%22">Sirima SB</searchLink>; Groupe de Recherche Action en Sante (GRAS), Ouagadougou, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Madhi+SA%22">Madhi SA</searchLink>; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Hill+AVS%22">Hill AVS</searchLink>; Centre for Human Genetics, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Prentice+AM%22">Prentice AM</searchLink>; MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, The Gambia.<br /><searchLink fieldCode="AU" term="%22Bejon+P%22">Bejon P</searchLink>; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Modernising Medical Microbiology Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hemani+G%22">Hemani G</searchLink>; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Smith+GD%22">Smith GD</searchLink>; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Sandhu+MS%22">Sandhu MS</searchLink>; Department of Epidemiology & Biostatistics, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Elliott+AM%22">Elliott AM</searchLink>; MRC/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Williams+TN%22">Williams TN</searchLink>; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.; Department of Surgery and Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Adeyemo+A%22">Adeyemo A</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Atkinson+SH%22">Atkinson SH</searchLink>; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. satkinson@kemri-wellcome.org.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. satkinson@kemri-wellcome.org.; Department of Paediatrics, University of Oxford, Oxford, UK. satkinson@kemri-wellcome.org.
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