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Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks.

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Title: Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks.
Authors: Mazzachi P; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., McDonald E; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Greenberg Z; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Puerta AN; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia., Tran J; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia., De Silva MI; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Christensen C; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia., Adams R; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Loskarn S; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia., Beard H; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Zabolocki M; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Elmasri M; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Maack M; Sanfilippo Children's Foundation, Sydney, NSW, Australia.; Childhood Dementia Initiative, Sydney, NSW, Australia., Elvidge KL; Sanfilippo Children's Foundation, Sydney, NSW, Australia.; Childhood Dementia Initiative, Sydney, NSW, Australia., Hutchinson MR; School of Biomedicine, Adelaide University, Adelaide, SA, Australia.; Institute for Photonic and Advanced Sensing, Adelaide University, Adelaide, SA, Australia., O'Neill C; Cure Sanfilippo Foundation, Columbia, SC, USA., Hemsley KM; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Melton L; Sanfilippo Children's Foundation, Sydney, NSW, Australia., Smith N; Department of Neurology and Clinical Neurophysiology, Women's and Children's Health Network, Adelaide, SA, Australia.; Paediatric Neurodegenerative Disease Research Group, Discipline of Paediatrics, College of Health, Adelaide University, Adelaide, SA, Australia., Bardy C; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia. cedric.bardy@flinders.edu.au.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia. cedric.bardy@flinders.edu.au.; Brain Organoid Therapeutics, Adelaide, SA, Australia. cedric.bardy@flinders.edu.au.
Source: Nature communications [Nat Commun] 2026 Apr 07; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks.
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  Data: <searchLink fieldCode="AU" term="%22Mazzachi+P%22">Mazzachi P</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22McDonald+E%22">McDonald E</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Greenberg+Z%22">Greenberg Z</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Puerta+AN%22">Puerta AN</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Tran+J%22">Tran J</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22De+Silva+MI%22">De Silva MI</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Christensen+C%22">Christensen C</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Adams+R%22">Adams R</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Loskarn+S%22">Loskarn S</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Beard+H%22">Beard H</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Zabolocki+M%22">Zabolocki M</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Elmasri+M%22">Elmasri M</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Maack+M%22">Maack M</searchLink>; Sanfilippo Children's Foundation, Sydney, NSW, Australia.; Childhood Dementia Initiative, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Elvidge+KL%22">Elvidge KL</searchLink>; Sanfilippo Children's Foundation, Sydney, NSW, Australia.; Childhood Dementia Initiative, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hutchinson+MR%22">Hutchinson MR</searchLink>; School of Biomedicine, Adelaide University, Adelaide, SA, Australia.; Institute for Photonic and Advanced Sensing, Adelaide University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22O'Neill+C%22">O'Neill C</searchLink>; Cure Sanfilippo Foundation, Columbia, SC, USA.<br /><searchLink fieldCode="AU" term="%22Hemsley+KM%22">Hemsley KM</searchLink>; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Melton+L%22">Melton L</searchLink>; Sanfilippo Children's Foundation, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Smith+N%22">Smith N</searchLink>; Department of Neurology and Clinical Neurophysiology, Women's and Children's Health Network, Adelaide, SA, Australia.; Paediatric Neurodegenerative Disease Research Group, Discipline of Paediatrics, College of Health, Adelaide University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Bardy+C%22">Bardy C</searchLink>; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia. cedric.bardy@flinders.edu.au.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia. cedric.bardy@flinders.edu.au.; Brain Organoid Therapeutics, Adelaide, SA, Australia. cedric.bardy@flinders.edu.au.
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