Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks.
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| Title: | Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks. |
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| Authors: | Mazzachi P; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., McDonald E; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Greenberg Z; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Puerta AN; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia., Tran J; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia., De Silva MI; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Christensen C; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia., Adams R; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Loskarn S; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia., Beard H; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Zabolocki M; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Elmasri M; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Maack M; Sanfilippo Children's Foundation, Sydney, NSW, Australia.; Childhood Dementia Initiative, Sydney, NSW, Australia., Elvidge KL; Sanfilippo Children's Foundation, Sydney, NSW, Australia.; Childhood Dementia Initiative, Sydney, NSW, Australia., Hutchinson MR; School of Biomedicine, Adelaide University, Adelaide, SA, Australia.; Institute for Photonic and Advanced Sensing, Adelaide University, Adelaide, SA, Australia., O'Neill C; Cure Sanfilippo Foundation, Columbia, SC, USA., Hemsley KM; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia., Melton L; Sanfilippo Children's Foundation, Sydney, NSW, Australia., Smith N; Department of Neurology and Clinical Neurophysiology, Women's and Children's Health Network, Adelaide, SA, Australia.; Paediatric Neurodegenerative Disease Research Group, Discipline of Paediatrics, College of Health, Adelaide University, Adelaide, SA, Australia., Bardy C; Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia. cedric.bardy@flinders.edu.au.; Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia. cedric.bardy@flinders.edu.au.; Brain Organoid Therapeutics, Adelaide, SA, Australia. cedric.bardy@flinders.edu.au. |
| Source: | Nature communications [Nat Commun] 2026 Apr 07; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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