Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank.
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| Title: | Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank. |
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| Authors: | Lee YH; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. HLEE73@mgh.harvard.edu.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. HLEE73@mgh.harvard.edu.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. HLEE73@mgh.harvard.edu.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. HLEE73@mgh.harvard.edu., Zhang Y; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Espinosa Dice AL; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Li JH; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Tubbs JD; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Feng YA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan., Ge T; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Maihofer AX; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Nievergelt CM; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Smoller JW; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Koenen KC; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Roberts AL; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Slopen N; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. nslopen@hsph.harvard.edu.; Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA. nslopen@hsph.harvard.edu. |
| Source: | Molecular psychiatry [Mol Psychiatry] 2026 Aug; Vol. 31 (8), pp. 4777-4786. Date of Electronic Publication: 2026 Apr 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41946832 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lee+YH%22">Lee YH</searchLink>; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. HLEE73@mgh.harvard.edu.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. HLEE73@mgh.harvard.edu.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. HLEE73@mgh.harvard.edu.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. HLEE73@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Espinosa+Dice+AL%22">Espinosa Dice AL</searchLink>; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Li+JH%22">Li JH</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tubbs+JD%22">Tubbs JD</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Feng+YA%22">Feng YA</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ge+T%22">Ge T</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Maihofer+AX%22">Maihofer AX</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nievergelt+CM%22">Nievergelt CM</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Smoller+JW%22">Smoller JW</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Koenen+KC%22">Koenen KC</searchLink>; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+AL%22">Roberts AL</searchLink>; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Slopen+N%22">Slopen N</searchLink>; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. nslopen@hsph.harvard.edu.; Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA. nslopen@hsph.harvard.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229607835%22">Molecular psychiatry</searchLink> [Mol Psychiatry] 2026 Aug; Vol. 31 (8), pp. 4777-4786. <i>Date of Electronic Publication: </i>2026 Apr 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+Specialist+Journals%22">Nature Publishing Group Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607835 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5578 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213594184%22">13594184 </searchLink><i>NLM ISO Abbreviation: </i>Mol Psychiatry <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41380-026-03553-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 4777 Titles: – TitleFull: Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lee YH – PersonEntity: Name: NameFull: Zhang Y – PersonEntity: Name: NameFull: Espinosa Dice AL – PersonEntity: Name: NameFull: Li JH – PersonEntity: Name: NameFull: Tubbs JD – PersonEntity: Name: NameFull: Feng YA – PersonEntity: Name: NameFull: Ge T – PersonEntity: Name: NameFull: Maihofer AX – PersonEntity: Name: NameFull: Nievergelt CM – PersonEntity: Name: NameFull: Smoller JW – PersonEntity: Name: NameFull: Koenen KC – PersonEntity: Name: NameFull: Roberts AL – PersonEntity: Name: NameFull: Slopen N IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2026 Aug Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1476-5578 Numbering: – Type: volume Value: 31 – Type: issue Value: 8 Titles: – TitleFull: Molecular psychiatry Type: main |
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