Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank.

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Title: Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank.
Authors: Lee YH; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. HLEE73@mgh.harvard.edu.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. HLEE73@mgh.harvard.edu.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. HLEE73@mgh.harvard.edu.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. HLEE73@mgh.harvard.edu., Zhang Y; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Espinosa Dice AL; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Li JH; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Tubbs JD; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Feng YA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan., Ge T; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Maihofer AX; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Nievergelt CM; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Smoller JW; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Koenen KC; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Roberts AL; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Slopen N; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. nslopen@hsph.harvard.edu.; Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA. nslopen@hsph.harvard.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Aug; Vol. 31 (8), pp. 4777-4786. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lee+YH%22">Lee YH</searchLink>; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. HLEE73@mgh.harvard.edu.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. HLEE73@mgh.harvard.edu.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. HLEE73@mgh.harvard.edu.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. HLEE73@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Espinosa+Dice+AL%22">Espinosa Dice AL</searchLink>; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Li+JH%22">Li JH</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tubbs+JD%22">Tubbs JD</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Feng+YA%22">Feng YA</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ge+T%22">Ge T</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Maihofer+AX%22">Maihofer AX</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nievergelt+CM%22">Nievergelt CM</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Smoller+JW%22">Smoller JW</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Koenen+KC%22">Koenen KC</searchLink>; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+AL%22">Roberts AL</searchLink>; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Slopen+N%22">Slopen N</searchLink>; Broad Trauma Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. nslopen@hsph.harvard.edu.; Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA. nslopen@hsph.harvard.edu.
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