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Integrating chemical, genetic, and feasibility assessments for anti-tubercular target validation.

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Title: Integrating chemical, genetic, and feasibility assessments for anti-tubercular target validation.
Authors: Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA. dis2003@med.cornell.edu., Berthel SJ; Panorama Global, Seattle, WA, USA., Boshoff HIM; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Krieger IV; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA., Sukheja P; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Panda S; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA., Rath S; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA., Briggs K; Gates Medical Research Institute, Cambridge, MA, USA., Bian X; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA., Rasheed S; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), PharmaScienceHub (PSH), Saarland University Campus, 66123, Saarbrücken, Germany., Cleghorn LAT; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Ghorpade S; Holistic Drug Discovery and Development (H3D) Centre, Department of Chemistry, University of Cape Town, Rondebosch, 7701, South Africa., Lamprecht DA; Holistic Drug Discovery and Development (H3D) Centre, Department of Chemistry, University of Cape Town, Rondebosch, 7701, South Africa., Fotouhi N; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, NY, USA., Müller R; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), PharmaScienceHub (PSH), Saarland University Campus, 66123, Saarbrücken, Germany., Nathan C; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA., Parish T; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK., Rhee K; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Warner P; Gates Foundation, Seattle, WA, USA., McNamara CW; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Rock JM; Laboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, 10065, USA., Sacchettini JC; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA., Mizrahi V; Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Cape Town, South Africa. Valerie.Mizrahi@uct.ac.za.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 May; Vol. 18 (5), pp. 1495-1507. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article; Review
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrating chemical, genetic, and feasibility assessments for anti-tubercular target validation.
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  Data: <searchLink fieldCode="AU" term="%22Schnappinger+D%22">Schnappinger D</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA. dis2003@med.cornell.edu.<br /><searchLink fieldCode="AU" term="%22Berthel+SJ%22">Berthel SJ</searchLink>; Panorama Global, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Boshoff+HIM%22">Boshoff HIM</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Krieger+IV%22">Krieger IV</searchLink>; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.<br /><searchLink fieldCode="AU" term="%22Sukheja+P%22">Sukheja P</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Panda+S%22">Panda S</searchLink>; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.<br /><searchLink fieldCode="AU" term="%22Rath+S%22">Rath S</searchLink>; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.<br /><searchLink fieldCode="AU" term="%22Briggs+K%22">Briggs K</searchLink>; Gates Medical Research Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bian+X%22">Bian X</searchLink>; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.<br /><searchLink fieldCode="AU" term="%22Rasheed+S%22">Rasheed S</searchLink>; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), PharmaScienceHub (PSH), Saarland University Campus, 66123, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Cleghorn+LAT%22">Cleghorn LAT</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Ghorpade+S%22">Ghorpade S</searchLink>; Holistic Drug Discovery and Development (H3D) Centre, Department of Chemistry, University of Cape Town, Rondebosch, 7701, South Africa.<br /><searchLink fieldCode="AU" term="%22Lamprecht+DA%22">Lamprecht DA</searchLink>; Holistic Drug Discovery and Development (H3D) Centre, Department of Chemistry, University of Cape Town, Rondebosch, 7701, South Africa.<br /><searchLink fieldCode="AU" term="%22Fotouhi+N%22">Fotouhi N</searchLink>; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Müller+R%22">Müller R</searchLink>; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), PharmaScienceHub (PSH), Saarland University Campus, 66123, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Nathan+C%22">Nathan C</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Parish+T%22">Parish T</searchLink>; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.<br /><searchLink fieldCode="AU" term="%22Rhee+K%22">Rhee K</searchLink>; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Warner+P%22">Warner P</searchLink>; Gates Foundation, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22McNamara+CW%22">McNamara CW</searchLink>; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rock+JM%22">Rock JM</searchLink>; Laboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Sacchettini+JC%22">Sacchettini JC</searchLink>; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.<br /><searchLink fieldCode="AU" term="%22Mizrahi+V%22">Mizrahi V</searchLink>; Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Cape Town, South Africa. Valerie.Mizrahi@uct.ac.za.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101487380 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-4684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217574676%22">17574676 </searchLink><i>NLM ISO Abbreviation: </i>EMBO Mol Med <i>Subsets: </i>MEDLINE
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