Novel Pyrazole-3-Cyano-2-Pyridinone Hybrids as Multitarget Anti-Inflammatory Agents: Synthesis, Computational Modeling, and Biological Evaluation.
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| Title: | Novel Pyrazole-3-Cyano-2-Pyridinone Hybrids as Multitarget Anti-Inflammatory Agents: Synthesis, Computational Modeling, and Biological Evaluation. |
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| Authors: | Hussein BRM; Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt., Salem IM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, New Assuit City, Assiut, 71515, Egypt., Aziz HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley University, New Valley, 72511, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley National University, New Valley, 72511, Egypt., Alshazly O; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524, Sohag, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag National University, Sohag, 82524, Egypt., Hofny HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524, Sohag, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag National University, Sohag, 82524, Egypt., Mohassab AM; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.; Medicinal Chemistry Department, Faculty of Pharmacy, Minia National University, New Minia, Egypt., Awan ZA; Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Mahmoud EM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.; Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Gifu, 501-1193, Japan., Bräse S; Institute for Biological and Chemical System, Karlsruhe Institute of Technology, Karlsruhe, 76131, Germany., Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley University, New Valley, 72511, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley National University, New Valley, 72511, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524, Sohag, Egypt. |
| Source: | Drug design, development and therapy [Drug Des Devel Ther] 2026 Apr 01; Vol. 20, pp. 570813. Date of Electronic Publication: 2026 Apr 01 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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