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A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.

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Title: A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.
Authors: Scholten GJ; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Grundmann C; NOVARTIS Pharma AG, Basel, Switzerland., Nordling Å; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Coskun C; NOVARTIS Pharma AG, Basel, Switzerland., Engelhardt V; NOVARTIS Pharma AG, Basel, Switzerland., Sadhasivam L; NOVARTIS Pharma AG, Basel, Switzerland., Einfalt T; NOVARTIS Pharma AG, Basel, Switzerland., Ingelman-Sundberg M; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., van Riet S; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Source: Clinical and translational science [Clin Transl Sci] 2026 Apr; Vol. 19 (4), pp. e70536.
Publication Type: Journal Article
Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="JN" term="%22101474067%22">Clinical and translational science</searchLink> [Clin Transl Sci] 2026 Apr; Vol. 19 (4), pp. e70536.
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              Text: 2026 Apr
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