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Species-specific cleavage of the autophagy adaptor p62 dictates responses to TNF.

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Title: Species-specific cleavage of the autophagy adaptor p62 dictates responses to TNF.
Authors: Nössing C; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK. Electronic address: christoph.noessing@meduniwien.ac.at., Troitskaya O; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Long JS; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Craxton A; MRC Toxicology Unit, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK., Brucoli M; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK., Anderson E; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Lilla S; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., McEwan DG; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Minton AR; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Barthet VJA; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK., O'Prey J; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Thomson G; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Nixon C; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Zanivan S; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK., Strathdee D; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., MacFarlane M; MRC Toxicology Unit, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK., Ryan KM; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK. Electronic address: kevin.ryan@glasgow.ac.uk.
Source: Molecular cell [Mol Cell] 2026 Apr 16; Vol. 86 (8), pp. 1574-1586.e11. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
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  Data: Species-specific cleavage of the autophagy adaptor p62 dictates responses to TNF.
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  Data: <searchLink fieldCode="AU" term="%22Nössing+C%22">Nössing C</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK. Electronic address: christoph.noessing@meduniwien.ac.at.<br /><searchLink fieldCode="AU" term="%22Troitskaya+O%22">Troitskaya O</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Long+JS%22">Long JS</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Craxton+A%22">Craxton A</searchLink>; MRC Toxicology Unit, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.<br /><searchLink fieldCode="AU" term="%22Brucoli+M%22">Brucoli M</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Anderson+E%22">Anderson E</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Lilla+S%22">Lilla S</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22McEwan+DG%22">McEwan DG</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Minton+AR%22">Minton AR</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Barthet+VJA%22">Barthet VJA</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22O'Prey+J%22">O'Prey J</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Thomson+G%22">Thomson G</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Nixon+C%22">Nixon C</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22Zanivan+S%22">Zanivan S</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Strathdee+D%22">Strathdee D</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.<br /><searchLink fieldCode="AU" term="%22MacFarlane+M%22">MacFarlane M</searchLink>; MRC Toxicology Unit, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.<br /><searchLink fieldCode="AU" term="%22Ryan+KM%22">Ryan KM</searchLink>; Tumour Cell Death and Autophagy Laboratory, Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK. Electronic address: kevin.ryan@glasgow.ac.uk.
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