View in EDS HTML Full Text PDF Full Text

L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial.

Saved in:
Bibliographic Details
Title: L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial.
Authors: Giordano FA; Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany. Frank.Giordano@umm.de.; DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany. Frank.Giordano@umm.de.; Mannheim Institute for Intelligent Systems in Medicine (MIISM), University of Heidelberg, Mannheim, Germany. Frank.Giordano@umm.de., Layer JP; Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.; Institute of Experimental Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany., Turiello R; Institute of Experimental Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany., Friker LL; Institute of Experimental Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.; Institute of Neuropathology, University Hospital Bonn, University of Bonn, Bonn, Germany., Mirallas O; Medical Oncology Department, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Pregler BEF; Department of Neurosurgery, University Hospital Bonn, University of Bonn, Bonn, Germany., Potthoff AL; Department of Neurosurgery, University Hospital Bonn, University of Bonn, Bonn, Germany., Zeyen T; Department of Neurooncology, University Hospital Bonn, University of Bonn, Bonn, Germany., Weller J; Department of Neurooncology, University Hospital Bonn, University of Bonn, Bonn, Germany., Sperk E; Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.; Mannheim Cancer Center, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany., Sahm K; Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany., Oster C; Department of Neurology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany., Kebir S; Department of Neurology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Hambsch P; Department of Radiation Oncology, University of Leipzig Medical Center, University of Leipzig, Leipzig, Germany., Schäfer N; Department of Neurooncology, University Hospital Bonn, University of Bonn, Bonn, Germany., Kadzik S; Institute of Experimental Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany., Renovanz M; Department of Neurology and Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Eberhard Karls University, Tübingen, Germany., Pietsch T; Institute of Neuropathology, University Hospital Bonn, University of Bonn, Bonn, Germany., Bisdas S; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom., Sepúlveda-Sánchez JM; Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain., Gómez-Puerto D; Medical Oncology Department, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Vieito M; Medical Oncology Department, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Platten M; Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany., Gkika E; Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany., Grauer OM; Department of Neurology, University Hospital Münster, University of Münster, Münster, Germany., Tabatabai G; Department of Neurology and Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Eberhard Karls University, Tübingen, Germany., Schneider M; Department of Neurosurgery, University Hospital Bonn, University of Bonn, Bonn, Germany., Glas M; Department of Neurology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany.; Department of Neurology and Neurooncology, St. Marien Hospital Lünen, Lünen, Germany., Seidel C; Department of Radiation Oncology, University of Leipzig Medical Center, University of Leipzig, Leipzig, Germany., Herrlinger U; Department of Neurooncology, University Hospital Bonn, University of Bonn, Bonn, Germany., Hölzel M; Institute of Experimental Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany. michael.hoelzel@ukbonn.de.
Source: Nature communications [Nat Commun] 2026 Apr 08; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41951573
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Giordano+FA%22">Giordano FA</searchLink>; Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany. Frank.Giordano@umm.de.; DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany. Frank.Giordano@umm.de.; Mannheim Institute for Intelligent Systems in Medicine (MIISM), University of Heidelberg, Mannheim, Germany. Frank.Giordano@umm.de.<br /><searchLink fieldCode="AU" term="%22Layer+JP%22">Layer JP</searchLink>; Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.; Institute of Experimental Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Turiello+R%22">Turiello R</searchLink>; Institute of Experimental Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Friker+LL%22">Friker LL</searchLink>; Institute of Experimental Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.; Institute of Neuropathology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Mirallas+O%22">Mirallas O</searchLink>; Medical Oncology Department, Vall d'Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pregler+BEF%22">Pregler BEF</searchLink>; Department of Neurosurgery, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Potthoff+AL%22">Potthoff AL</searchLink>; Department of Neurosurgery, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Zeyen+T%22">Zeyen T</searchLink>; Department of Neurooncology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Weller+J%22">Weller J</searchLink>; Department of Neurooncology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Sperk+E%22">Sperk E</searchLink>; Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.; Mannheim Cancer Center, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Sahm+K%22">Sahm K</searchLink>; Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Oster+C%22">Oster C</searchLink>; Department of Neurology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Kebir+S%22">Kebir S</searchLink>; Department of Neurology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hambsch+P%22">Hambsch P</searchLink>; Department of Radiation Oncology, University of Leipzig Medical Center, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schäfer+N%22">Schäfer N</searchLink>; Department of Neurooncology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kadzik+S%22">Kadzik S</searchLink>; Institute of Experimental Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Renovanz+M%22">Renovanz M</searchLink>; Department of Neurology and Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Eberhard Karls University, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Pietsch+T%22">Pietsch T</searchLink>; Institute of Neuropathology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Bisdas+S%22">Bisdas S</searchLink>; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sepúlveda-Sánchez+JM%22">Sepúlveda-Sánchez JM</searchLink>; Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Puerto+D%22">Gómez-Puerto D</searchLink>; Medical Oncology Department, Vall d'Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vieito+M%22">Vieito M</searchLink>; Medical Oncology Department, Vall d'Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Platten+M%22">Platten M</searchLink>; Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gkika+E%22">Gkika E</searchLink>; Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Grauer+OM%22">Grauer OM</searchLink>; Department of Neurology, University Hospital Münster, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Tabatabai+G%22">Tabatabai G</searchLink>; Department of Neurology and Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Eberhard Karls University, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+M%22">Schneider M</searchLink>; Department of Neurosurgery, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Glas+M%22">Glas M</searchLink>; Department of Neurology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany.; Department of Neurology and Neurooncology, St. Marien Hospital Lünen, Lünen, Germany.<br /><searchLink fieldCode="AU" term="%22Seidel+C%22">Seidel C</searchLink>; Department of Radiation Oncology, University of Leipzig Medical Center, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Herrlinger+U%22">Herrlinger U</searchLink>; Department of Neurooncology, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Hölzel+M%22">Hölzel M</searchLink>; Institute of Experimental Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany. michael.hoelzel@ukbonn.de.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Apr 08; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Apr 08.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41951573
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-026-71362-7
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Giordano FA
      – PersonEntity:
          Name:
            NameFull: Layer JP
      – PersonEntity:
          Name:
            NameFull: Turiello R
      – PersonEntity:
          Name:
            NameFull: Friker LL
      – PersonEntity:
          Name:
            NameFull: Mirallas O
      – PersonEntity:
          Name:
            NameFull: Pregler BEF
      – PersonEntity:
          Name:
            NameFull: Potthoff AL
      – PersonEntity:
          Name:
            NameFull: Zeyen T
      – PersonEntity:
          Name:
            NameFull: Weller J
      – PersonEntity:
          Name:
            NameFull: Sperk E
      – PersonEntity:
          Name:
            NameFull: Sahm K
      – PersonEntity:
          Name:
            NameFull: Oster C
      – PersonEntity:
          Name:
            NameFull: Kebir S
      – PersonEntity:
          Name:
            NameFull: Hambsch P
      – PersonEntity:
          Name:
            NameFull: Schäfer N
      – PersonEntity:
          Name:
            NameFull: Kadzik S
      – PersonEntity:
          Name:
            NameFull: Renovanz M
      – PersonEntity:
          Name:
            NameFull: Pietsch T
      – PersonEntity:
          Name:
            NameFull: Bisdas S
      – PersonEntity:
          Name:
            NameFull: Sepúlveda-Sánchez JM
      – PersonEntity:
          Name:
            NameFull: Gómez-Puerto D
      – PersonEntity:
          Name:
            NameFull: Vieito M
      – PersonEntity:
          Name:
            NameFull: Platten M
      – PersonEntity:
          Name:
            NameFull: Gkika E
      – PersonEntity:
          Name:
            NameFull: Grauer OM
      – PersonEntity:
          Name:
            NameFull: Tabatabai G
      – PersonEntity:
          Name:
            NameFull: Schneider M
      – PersonEntity:
          Name:
            NameFull: Glas M
      – PersonEntity:
          Name:
            NameFull: Seidel C
      – PersonEntity:
          Name:
            NameFull: Herrlinger U
      – PersonEntity:
          Name:
            NameFull: Hölzel M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 08
              M: 04
              Text: 2026 Apr 08
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1