Cell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro.

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Title: Cell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro.
Authors: Piskova T; Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, Germany., Kozyrina AN; Centre for the Cellular Microenvironment, James Watt School of Engineering, University of Glasgow, Glasgow, UK., Astrauskaitė G; Centre for the Cellular Microenvironment, James Watt School of Engineering, University of Glasgow, Glasgow, UK., Mabrouk ME; Institute of Stem Cell Biology, University Hospital of RWTH Aachen, Aachen, Germany., Schepl S; Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, Germany., Yam SLS; Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, Germany., Ravithas R; Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, Germany., Wagner W; Institute of Stem Cell Biology, University Hospital of RWTH Aachen, Aachen, Germany., Vassalli M; Centre for the Cellular Microenvironment, James Watt School of Engineering, University of Glasgow, Glasgow, UK., Di Russo J; Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, Germany. jdirusso@ukaachen.de.; DWI-Leibniz-Institute for Interactive Materials, Aachen, Germany. jdirusso@ukaachen.de.
Source: Nature communications [Nat Commun] 2026 Apr 08; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-71493-x