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Intranasal co-delivery of riluzole and berberine via chitosan-coated PLGA nanoparticles for synergistic neuroprotection in Alzheimer's disease: formulation, characterization, and pharmacokinetics analysis.

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Title: Intranasal co-delivery of riluzole and berberine via chitosan-coated PLGA nanoparticles for synergistic neuroprotection in Alzheimer's disease: formulation, characterization, and pharmacokinetics analysis.
Authors: Komy MHE; Department of Pharmaceutics, College of Pharmacy, Jouf University, 72341, Sakaka, Saudi Arabia. mhalkomy@ju.edu.sa., Aldosari BN; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, 11451, Saudi Arabia., Zaki RM; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, P.O. Box 173, 11942, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt., Bafail R; Department of Pharmaceutics and Pharmaceutical Industries, College of Pharmacy, Taibah University, Al-Madinah, Al-Munawarah, P.O. Box 30039, 41477, Saudi Arabia., Yusif RM; Department of Pharmaceutics and Pharmaceutical Industries, College of Pharmacy, Taibah University, Al-Madinah, Al-Munawarah, P.O. Box 30039, 41477, Saudi Arabia.; Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, P.O. Box 35516, Egypt., Abdelgawad MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, 72341, Saudi Arabia., Elmowafy M; Department of Pharmaceutics, College of Pharmacy, Jouf University, 72341, Sakaka, Saudi Arabia., Abuhelwa AY; Department of Pharmacy Practice and Pharmacotherapeutics, University of Sharjah, Sharjah, United Arab Emirates.; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates., Eid HM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt. hussien.eid@pharm.bsu.edu.eg.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jun; Vol. 399 (9), pp. 14123-14140. Date of Electronic Publication: 2026 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
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  Data: Intranasal co-delivery of riluzole and berberine via chitosan-coated PLGA nanoparticles for synergistic neuroprotection in Alzheimer's disease: formulation, characterization, and pharmacokinetics analysis.
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  Data: <searchLink fieldCode="AU" term="%22Komy+MHE%22">Komy MHE</searchLink>; Department of Pharmaceutics, College of Pharmacy, Jouf University, 72341, Sakaka, Saudi Arabia. mhalkomy@ju.edu.sa.<br /><searchLink fieldCode="AU" term="%22Aldosari+BN%22">Aldosari BN</searchLink>; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Zaki+RM%22">Zaki RM</searchLink>; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, P.O. Box 173, 11942, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt.<br /><searchLink fieldCode="AU" term="%22Bafail+R%22">Bafail R</searchLink>; Department of Pharmaceutics and Pharmaceutical Industries, College of Pharmacy, Taibah University, Al-Madinah, Al-Munawarah, P.O. Box 30039, 41477, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Yusif+RM%22">Yusif RM</searchLink>; Department of Pharmaceutics and Pharmaceutical Industries, College of Pharmacy, Taibah University, Al-Madinah, Al-Munawarah, P.O. Box 30039, 41477, Saudi Arabia.; Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, P.O. Box 35516, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelgawad+MA%22">Abdelgawad MA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, 72341, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Elmowafy+M%22">Elmowafy M</searchLink>; Department of Pharmaceutics, College of Pharmacy, Jouf University, 72341, Sakaka, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abuhelwa+AY%22">Abuhelwa AY</searchLink>; Department of Pharmacy Practice and Pharmacotherapeutics, University of Sharjah, Sharjah, United Arab Emirates.; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Eid+HM%22">Eid HM</searchLink>; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt. hussien.eid@pharm.bsu.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%220326264%22">Naunyn-Schmiedeberg's archives of pharmacology</searchLink> [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jun; Vol. 399 (9), pp. 14123-14140. <i>Date of Electronic Publication: </i>2026 Apr 09.
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              Text: 2026 Jun
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