Exogenous lactate administration alleviates post-cardiac arrest brain injury by coordinating metabolic reprogramming and pathological mitophagy suppression.
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| Title: | Exogenous lactate administration alleviates post-cardiac arrest brain injury by coordinating metabolic reprogramming and pathological mitophagy suppression. |
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| Authors: | Wu C; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China.; Anesthesia Center of Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA., Zhang W; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China., Lin Y; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China., Lin M; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China., Rao T; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China., Chen Z; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China., Zhang X; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China., Xu J; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China. z2jeffxu@zju.edu.cn., Zhang M; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China. z2jzk@zju.edu.cn. |
| Source: | Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Apr 09; Vol. 83 (1). Date of Electronic Publication: 2026 Apr 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41951960 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Exogenous lactate administration alleviates post-cardiac arrest brain injury by coordinating metabolic reprogramming and pathological mitophagy suppression. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China.; Anesthesia Center of Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China.<br /><searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China.<br /><searchLink fieldCode="AU" term="%22Rao+T%22">Rao T</searchLink>; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China. z2jeffxu@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Emergency Medicine, Zhejiang Key Laboratory of Trauma, Burn, and Medical Rescue, Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, 310009, China. z2jzk@zju.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2026 Apr 09; Vol. 83 (1). <i>Date of Electronic Publication: </i>2026 Apr 09. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41951960 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00018-026-06190-5 Languages: – Code: eng Text: English Titles: – TitleFull: Exogenous lactate administration alleviates post-cardiac arrest brain injury by coordinating metabolic reprogramming and pathological mitophagy suppression. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wu C – PersonEntity: Name: NameFull: Zhang W – PersonEntity: Name: NameFull: Lin Y – PersonEntity: Name: NameFull: Lin M – PersonEntity: Name: NameFull: Rao T – PersonEntity: Name: NameFull: Chen Z – PersonEntity: Name: NameFull: Zhang X – PersonEntity: Name: NameFull: Xu J – PersonEntity: Name: NameFull: Zhang M IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 04 Text: 2026 Apr 09 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1420-9071 Numbering: – Type: volume Value: 83 – Type: issue Value: 1 Titles: – TitleFull: Cellular and molecular life sciences : CMLS Type: main |
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