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A murine model of sepsis induces age- and sex-specific chromatin remodeling in myeloid-derived suppressor cells.

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Title: A murine model of sepsis induces age- and sex-specific chromatin remodeling in myeloid-derived suppressor cells.
Authors: Charles AM; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States., Rodhouse CE; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States., Darden DB; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States., Gauthier ML; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, United States., Zhou M; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, United States., Hernandez-Rios M; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States., Wang D; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, United States., Casadesus G; Department of Pharmacy and Therapeutics, University of Florida College of Medicine, Gainesville, FL, United States., Bible L; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States., Mohr AM; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States., Xiao F; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, United States., Cai G; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, United States., Brant JO; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, United States., Wallet SM; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, United States., Mathews CE; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States., Moldawer LL; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States., Chakrabarty P; Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL, United States., Bacher RL; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, United States., Efron PA; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States., Maile R; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States., Kladde MP; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, United States.; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, United States.
Source: Frontiers in immunology [Front Immunol] 2026 Mar 24; Vol. 17, pp. 1750174. Date of Electronic Publication: 2026 Mar 24 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: A murine model of sepsis induces age- and sex-specific chromatin remodeling in myeloid-derived suppressor cells.
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Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Casadesus+G%22">Casadesus G</searchLink>; Department of Pharmacy and Therapeutics, University of Florida College of Medicine, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Bible+L%22">Bible L</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Mohr+AM%22">Mohr AM</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Xiao+F%22">Xiao F</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Cai+G%22">Cai G</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Brant+JO%22">Brant JO</searchLink>; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Wallet+SM%22">Wallet SM</searchLink>; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Mathews+CE%22">Mathews CE</searchLink>; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Moldawer+LL%22">Moldawer LL</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Chakrabarty+P%22">Chakrabarty P</searchLink>; Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Bacher+RL%22">Bacher RL</searchLink>; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Efron+PA%22">Efron PA</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Maile+R%22">Maile R</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Kladde+MP%22">Kladde MP</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States.; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, United States.; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, United States.
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