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Efficacy and safety of semaglutide injection in comparison with reference semaglutide for chronic weight management in indian adults with obesity: A phase III randomized non-inferiority trial.

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Title: Efficacy and safety of semaglutide injection in comparison with reference semaglutide for chronic weight management in indian adults with obesity: A phase III randomized non-inferiority trial.
Authors: Sharma PK; Department of Medicine, Maharaja Agrasen Superspeciality Hospital, Central Spine, Agrasen Aspatal Marg, Sector 7, Vidyadhar Nagar, Jaipur, 302039, Rajasthan, Jaipur, 302039, Rajasthan, India., Redkar SV; Department of Medicine, Redkar Hospital and Research Centre, Mumbai-Goa Highway, Oxelbag, Dhargal, Tal-Pernem, Goa, 403513, North Goa, 403513, Goa, India., Madhav Karmalkar A; Department of Medicine, Vedant Multispeciality Hospital, GP-83, Opp. to Rotary Club, Sambhaji Nagar, MIDC, Chinchwad, Pune, 411019, Maharashtra, Pune, 411019, Maharashtra, India., Anand S; Department of Medicine, NIMS Heart and Brain Hospital, B28, 29, Govind Marg, Raja Park, Jaipur, 302004, Rajasthan, Jaipur, 302004, Rajasthan, India., Patil VS; Department of Medicine, Prakash Institute of Medical Sciences & Research (PIMS&R), Urun-Islampur, Islampur-Sangali Road, Islampur, Tal-Walwa, Dist-Sangali, 415409, Maharashtra, Sangali, 415409, Maharashtra, India., Nurulhasan AR; Department of Medicine, Hope Well Medical Hospital, Block G, 1st Floor, 101, 102, Sumel-8, Nr. Ajit Mill Char Rasta, Rakhiyal, Ahmedabad, 380023, Gujarat, Ahmedabad, 380023, Gujarat, India., Manan Bharatkumar P; Department of Medicine, Ananta Multispeciality Hospital, 4th Floor (416-418) Centre Point, Opp. Vrundavan Heights, Vande Mataram City to Savvy Swaraj Road, Chenpur, Gota, Ahmedabad, 382470, Gujarat, Ahmedabad, 382470, Gujarat, India., Barge V; Department of Medicine, Rajarshee Chhatrapati Shahu Maharaj Govt. Medical College and Chhatrapati Pramila Raje General Hospital, Dasara Chowk, Town Hall, Bhausingji Road, Kolhapur, 416012, Maharashtra, Kolhapur, 416012, Maharashtra, India., Shah SJ; Department of Medicine, Sheth Vadilal Sarabhai General Hospital & Sheth Chinai Maternity Hospital, Madalpur Gam, Paldi Road, Ellisbridge, Paldi, Ahmedabad, 380006, Gujarat, Ahmedabad, 380006, Gujarat, India., Patel CB; Department of Medicine, Aatman Hospital, 5, Anveshan Row House, Opp. Umiya Mata Mandir, Bopal-Ghuma Main Road, Bopal, Ahmedabad, 380058, Gujarat, India., Choudhary A; Department of Medicine, SMC Heart Institute and IVF Research Centre, Infront of BSNL Office, Vidhan Sabha Road, Khamardih, Raipur, 492007, Chhattisgarh, Raipur, 492007, Chhattisgarh, India., Sudheer K; Department of General Medicine, Great Eastern Medical School and Hospital, Ragolu, Srikakulam, 532484, Andhra Pradesh, Srikakulam, 532484, Andhra Pradesh, India., Rambabu K; Department of General Medicine, Visakha Institute of Medical Sciences, NH-16, Hanumanthavaka Junction, Visakhapatnam, 530040, Andhra Pradesh, Visakhapatnam, 530040, Andhra Pradesh, India., Narasinga Rao S; Department of Medicine, Rajendra Prasad Ward, Maharanipeta, Visakhapatnam, 530002, Andhra Pradesh, Visakhapatnam, 530040, Andhra Pradesh, India., Swapna M; Department of General Medicine, In Patient Block, 3rd Floor, Gandhi Hospital, Musheerabad, Secunderabad, 500003, Telangana, Secunderabad, 500003, Telangana, India., Ankathi SK; Department of Endocrinology, Mahatma Gandhi Memorial Hospital, Sherpura, Warangal, 506002, Telangana, Warangal, 506002, Telangana, India., Singh VB; Department of Medicine, Sardar Patel Medical College & A.G. Hospitals, Sardar Patel Colony, Bikaner, 334001, Rajasthan, Bikaner, 334001, Rajasthan, India., Sarkar G; Department of General Medicine, Life Line Diagnostic Centre Cum Nursing Home, 4A, Wood Street, Kolkata, 700016, West Bengal, Kolkata, 700016, West Bengal, India., Gautam SK; Post Graduate Department of Medicine, LLR Hospital, GSVM Medical, College, Swaroop Nagar, Kanpur, 208002, Uttar Pradesh, Kanpur, 208002, Uttar Pradesh, India., Das KK; Department of Medicine, Aastha Hospital, Beside NBMCH, Opp. Bharat Petrol Pump, Kawakhari, Siliguri, 734012, West Bengal, Siliguri, 734012, West Bengal, India., Bhattacharya R; Department of Medicine, Medical College and Hospital, Kolkata, MCH Building, 4th Floor, 88 College Street, Kolkata, 700073, West Bengal, India., Tripathi KN; Department of Medicine, Motilal Nehru Medical College & Associate Swarooprani Nehru Hospital, Prayagraj, 211001, Uttar Pradesh, Prayagraj, 211001, Uttar Pradesh, India., Sudarsi B; Department of General Medicine, Government General Hospital, Cantonment, Vizianagaram, 535003, Andhra Pradesh, India., Parmar D; Clinical R & D, Zydus Research Centre, Sarkhej-Bavla National Highway No. 8A Moraiya, Ahmedabad, 382213, Gujarat, India, Ahmedabad, 382213, Gujarat, India., Kansagra K; Clinical R & D, Zydus Research Centre, Sarkhej-Bavla National Highway No. 8A Moraiya, Ahmedabad, 382213, Gujarat, India, Ahmedabad, 382213, Gujarat, India., Pathak H; Clinical R & D, Zydus Research Centre, Sarkhej-Bavla National Highway No. 8A Moraiya, Ahmedabad, 382213, Gujarat, India, Ahmedabad, 382213, Gujarat, India.
Source: Metabolism open [Metabol Open] 2026 Mar 23; Vol. 30, pp. 100460. Date of Electronic Publication: 2026 Mar 23 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: England NLM ID: 101767753 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-9368 (Electronic) Linking ISSN: 25899368 NLM ISO Abbreviation: Metabol Open Subsets: PubMed not MEDLINE
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  Data: Efficacy and safety of semaglutide injection in comparison with reference semaglutide for chronic weight management in indian adults with obesity: A phase III randomized non-inferiority trial.
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  Data: <searchLink fieldCode="AU" term="%22Sharma+PK%22">Sharma PK</searchLink>; Department of Medicine, Maharaja Agrasen Superspeciality Hospital, Central Spine, Agrasen Aspatal Marg, Sector 7, Vidyadhar Nagar, Jaipur, 302039, Rajasthan, Jaipur, 302039, Rajasthan, India.<br /><searchLink fieldCode="AU" term="%22Redkar+SV%22">Redkar SV</searchLink>; Department of Medicine, Redkar Hospital and Research Centre, Mumbai-Goa Highway, Oxelbag, Dhargal, Tal-Pernem, Goa, 403513, North Goa, 403513, Goa, India.<br /><searchLink fieldCode="AU" term="%22Madhav+Karmalkar+A%22">Madhav Karmalkar A</searchLink>; Department of Medicine, Vedant Multispeciality Hospital, GP-83, Opp. to Rotary Club, Sambhaji Nagar, MIDC, Chinchwad, Pune, 411019, Maharashtra, Pune, 411019, Maharashtra, India.<br /><searchLink fieldCode="AU" term="%22Anand+S%22">Anand S</searchLink>; Department of Medicine, NIMS Heart and Brain Hospital, B28, 29, Govind Marg, Raja Park, Jaipur, 302004, Rajasthan, Jaipur, 302004, Rajasthan, India.<br /><searchLink fieldCode="AU" term="%22Patil+VS%22">Patil VS</searchLink>; Department of Medicine, Prakash Institute of Medical Sciences & Research (PIMS&R), Urun-Islampur, Islampur-Sangali Road, Islampur, Tal-Walwa, Dist-Sangali, 415409, Maharashtra, Sangali, 415409, Maharashtra, India.<br /><searchLink fieldCode="AU" term="%22Nurulhasan+AR%22">Nurulhasan AR</searchLink>; Department of Medicine, Hope Well Medical Hospital, Block G, 1st Floor, 101, 102, Sumel-8, Nr. 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