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Meloaxilines A-E, five unprecedented monoterpenoid indole alkaloids from Melodinus axillaris, suppress colorectal cancer by targeting the iron metabolism pathway.

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Title: Meloaxilines A-E, five unprecedented monoterpenoid indole alkaloids from Melodinus axillaris, suppress colorectal cancer by targeting the iron metabolism pathway.
Authors: Du KC; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China., Li GC; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China., Li YH; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China., Xu XB; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China., Hua HM; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Kongkatitham V; Center of Excellence in Natural Products for Ageing and Chronic Diseases, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand., Wang YM; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: WYM9585@163.com., Rojsitthisak P; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China; Center of Excellence in Natural Products for Ageing and Chronic Diseases, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: pornchai.r@chula.ac.th., Meng DL; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: mengdl@163.com.
Source: Bioorganic chemistry [Bioorg Chem] 2026 Jul 15; Vol. 176, pp. 109845. Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Meloaxilines A-E, five unprecedented monoterpenoid indole alkaloids from Melodinus axillaris, suppress colorectal cancer by targeting the iron metabolism pathway.
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  Data: <searchLink fieldCode="AU" term="%22Du+KC%22">Du KC</searchLink>; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.<br /><searchLink fieldCode="AU" term="%22Li+GC%22">Li GC</searchLink>; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.<br /><searchLink fieldCode="AU" term="%22Li+YH%22">Li YH</searchLink>; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.<br /><searchLink fieldCode="AU" term="%22Xu+XB%22">Xu XB</searchLink>; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.<br /><searchLink fieldCode="AU" term="%22Hua+HM%22">Hua HM</searchLink>; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.<br /><searchLink fieldCode="AU" term="%22Kongkatitham+V%22">Kongkatitham V</searchLink>; Center of Excellence in Natural Products for Ageing and Chronic Diseases, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.<br /><searchLink fieldCode="AU" term="%22Wang+YM%22">Wang YM</searchLink>; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: WYM9585@163.com.<br /><searchLink fieldCode="AU" term="%22Rojsitthisak+P%22">Rojsitthisak P</searchLink>; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China; Center of Excellence in Natural Products for Ageing and Chronic Diseases, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: pornchai.r@chula.ac.th.<br /><searchLink fieldCode="AU" term="%22Meng+DL%22">Meng DL</searchLink>; Key Labzoratory of Ethnomedicine Material Basis & Pharmacological Mechanisms, Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: mengdl@163.com.
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              Text: 2026 Jul 15
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