Fine-tuning the combination of novel spirocyclic capping moieties and heterocyclic zinc binding groups for selective HDAC6 inhibition: design, synthesis, kinetic and biological studies.

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Title: Fine-tuning the combination of novel spirocyclic capping moieties and heterocyclic zinc binding groups for selective HDAC6 inhibition: design, synthesis, kinetic and biological studies.
Authors: Barone S; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Bello I; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Filocamo G; Exiris s.r.l., Via di Castel Romano, 100, Rome, 00128, Italy., Cerchia C; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Guadagni A; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Brunetti M; Exiris s.r.l., Via di Castel Romano, 100, Rome, 00128, Italy., Cosentino E; Exiris s.r.l., Via di Castel Romano, 100, Rome, 00128, Italy., Hanl M; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany., König B; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany., Esposito C; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Schäker-Hübner L; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany., Summa V; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Panza E; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Hansen FK; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany., Brindisi M; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy. Electronic address: margherita.brindisi@unina.it.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Jul 05; Vol. 311, pp. 118806. Date of Electronic Publication: 2026 Mar 29.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1768-3254
DOI:10.1016/j.ejmech.2026.118806