View in EDS

Fine-tuning the combination of novel spirocyclic capping moieties and heterocyclic zinc binding groups for selective HDAC6 inhibition: design, synthesis, kinetic and biological studies.

Saved in:
Bibliographic Details
Title: Fine-tuning the combination of novel spirocyclic capping moieties and heterocyclic zinc binding groups for selective HDAC6 inhibition: design, synthesis, kinetic and biological studies.
Authors: Barone S; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Bello I; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Filocamo G; Exiris s.r.l., Via di Castel Romano, 100, Rome, 00128, Italy., Cerchia C; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Guadagni A; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Brunetti M; Exiris s.r.l., Via di Castel Romano, 100, Rome, 00128, Italy., Cosentino E; Exiris s.r.l., Via di Castel Romano, 100, Rome, 00128, Italy., Hanl M; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany., König B; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany., Esposito C; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Schäker-Hübner L; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany., Summa V; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Panza E; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy., Hansen FK; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany., Brindisi M; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy. Electronic address: margherita.brindisi@unina.it.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Jul 05; Vol. 311, pp. 118806. Date of Electronic Publication: 2026 Mar 29.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41955939
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Fine-tuning the combination of novel spirocyclic capping moieties and heterocyclic zinc binding groups for selective HDAC6 inhibition: design, synthesis, kinetic and biological studies.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Barone+S%22">Barone S</searchLink>; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Bello+I%22">Bello I</searchLink>; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Filocamo+G%22">Filocamo G</searchLink>; Exiris s.r.l., Via di Castel Romano, 100, Rome, 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Cerchia+C%22">Cerchia C</searchLink>; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Guadagni+A%22">Guadagni A</searchLink>; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Brunetti+M%22">Brunetti M</searchLink>; Exiris s.r.l., Via di Castel Romano, 100, Rome, 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Cosentino+E%22">Cosentino E</searchLink>; Exiris s.r.l., Via di Castel Romano, 100, Rome, 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Hanl+M%22">Hanl M</searchLink>; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany.<br /><searchLink fieldCode="AU" term="%22König+B%22">König B</searchLink>; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany.<br /><searchLink fieldCode="AU" term="%22Esposito+C%22">Esposito C</searchLink>; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Schäker-Hübner+L%22">Schäker-Hübner L</searchLink>; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany.<br /><searchLink fieldCode="AU" term="%22Summa+V%22">Summa V</searchLink>; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Panza+E%22">Panza E</searchLink>; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Hansen+FK%22">Hansen FK</searchLink>; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, Bonn, 53121, Germany.<br /><searchLink fieldCode="AU" term="%22Brindisi+M%22">Brindisi M</searchLink>; Department of Pharmacy, Department of Excellence 2023-2027, University of Naples Federico II, Via D. Montesano 49, Naples, 80131, Italy. Electronic address: margherita.brindisi@unina.it.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Jul 05; Vol. 311, pp. 118806. <i>Date of Electronic Publication: </i>2026 Mar 29.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41955939
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.ejmech.2026.118806
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 118806
    Titles:
      – TitleFull: Fine-tuning the combination of novel spirocyclic capping moieties and heterocyclic zinc binding groups for selective HDAC6 inhibition: design, synthesis, kinetic and biological studies.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Barone S
      – PersonEntity:
          Name:
            NameFull: Bello I
      – PersonEntity:
          Name:
            NameFull: Filocamo G
      – PersonEntity:
          Name:
            NameFull: Cerchia C
      – PersonEntity:
          Name:
            NameFull: Guadagni A
      – PersonEntity:
          Name:
            NameFull: Brunetti M
      – PersonEntity:
          Name:
            NameFull: Cosentino E
      – PersonEntity:
          Name:
            NameFull: Hanl M
      – PersonEntity:
          Name:
            NameFull: König B
      – PersonEntity:
          Name:
            NameFull: Esposito C
      – PersonEntity:
          Name:
            NameFull: Schäker-Hübner L
      – PersonEntity:
          Name:
            NameFull: Summa V
      – PersonEntity:
          Name:
            NameFull: Panza E
      – PersonEntity:
          Name:
            NameFull: Hansen FK
      – PersonEntity:
          Name:
            NameFull: Brindisi M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 05
              M: 07
              Text: 2026 Jul 05
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1768-3254
          Numbering:
            – Type: volume
              Value: 311
          Titles:
            – TitleFull: European journal of medicinal chemistry
              Type: main
ResultId 1