Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor.
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| Title: | Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor. |
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| Authors: | Renner M; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany., Oleś M; Computational Oncology Group, Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Paramasivam N; Computational Oncology Group, Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Heilig CE; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany., Schneider A; School of Life Sciences, Technical University Munich, Freising, Germany.; DKTK, Partner Site Munich, Munich, Germany., Modugno C; Service d'Hémato-Oncologie, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg., Herremans C; Service d'Hémato-Oncologie, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg., Hüllein J; Computational Oncology Group, Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Hutter B; Computational Oncology Group, Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Erkut C; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Division of Applied Functional Genomics, DKFZ, Heidelberg, Germany., Mock A; DKTK, Partner Site Munich, Munich, Germany.; Institute of Pathology, Ludwig Maximilians University Munich, Munich, Germany., Krieghoff-Henning E; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Personalized Medical Oncology, DKFZ, Heidelberg, Germany.; Department of Personalized Oncology, DKFZ-Hector Cancer Institute, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Personalized Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Jensen CB; School of Life Sciences, Technical University Munich, Freising, Germany., Sakhteman A; School of Life Sciences, Technical University Munich, Freising, Germany., The M; School of Life Sciences, Technical University Munich, Freising, Germany., Prinz T; Institute for Clinical Genetics, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology (TUD), Dresden, Germany.; European Reference Network on Genetic Tumour Risk Syndromes, Hereditary Cancer Syndrome Center Dresden, Dresden, Germany.; DKTK, Partner Site Dresden, Dresden, Germany.; DKFZ, Heidelberg, Germany., Lajer P; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany., Baude-Müller A; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany., Beck K; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany., Beuthien-Baumann B; Division of Radiology, DKFZ, Heidelberg, Germany., Apostolidis L; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Medical Oncology, Heidelberg University Hospital, Heidelberg, Germany., Bauer S; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.; DKTK, Partner Site Essen, Essen, Germany., Boerries M; Comprehensive Cancer Center Freiburg, University of Freiburg Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute of Medical Bioinformatics and Systems Medicine, University of Freiburg Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; DKTK, Partner Site Freiburg, Freiburg, Germany., Brandts CH; University Cancer Center (UCT) Frankfurt, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.; Department of Medicine, Hematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.; Frankfurt Cancer Institute, Frankfurt, Germany.; DKTK, Partner Site Frankfurt, Frankfurt, Germany., Rieke DT; Charité Comprehensive Cancer Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.; DKTK, Partner Site Berlin, Berlin, Germany., Kindler T; UCT Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.; Department of Hematology and Medical Oncology, University Medical Center, Mainz, Germany.; DKTK, Partner Site Mainz, Mainz, Germany., Klauschen F; DKTK, Partner Site Munich, Munich, Germany.; Institute of Pathology, Ludwig Maximilians University Munich, Munich, Germany.; Berlin Institute for the Foundations of Learning and Data, Berlin, Germany., Schulze-Osthoff K; Department of Molecular Medicine, Interfaculty Institute for Biochemistry, University of Tübingen, Tübingen, Germany.; DKTK, Partner Site Tübingen, Tübingen, Germany., Schlenk RF; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Department of Medical Oncology, Heidelberg University Hospital, Heidelberg, Germany.; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Trial Center, NCT Heidelberg, Heidelberg, Germany., Berchem G; Service d'Hémato-Oncologie, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg., Allgäuer M; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Mechtersheimer G; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Stenzinger A; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Lipka DB; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany., Schlesner M; Biomedical Informatics, Data Mining and Data Analytics, Faculty of Applied Computer Science and Medical Faculty, University of Augsburg, Augsburg, Germany., Kuster B; School of Life Sciences, Technical University Munich, Freising, Germany.; DKTK, Partner Site Munich, Munich, Germany., Jahn A; Institute for Clinical Genetics, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology (TUD), Dresden, Germany.; European Reference Network on Genetic Tumour Risk Syndromes, Hereditary Cancer Syndrome Center Dresden, Dresden, Germany.; DKTK, Partner Site Dresden, Dresden, Germany.; DKFZ, Heidelberg, Germany.; NCT, NCT/University Cancer Center (UCC) Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany., Schröck E; Institute for Clinical Genetics, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology (TUD), Dresden, Germany.; European Reference Network on Genetic Tumour Risk Syndromes, Hereditary Cancer Syndrome Center Dresden, Dresden, Germany.; DKTK, Partner Site Dresden, Dresden, Germany.; DKFZ, Heidelberg, Germany.; NCT, NCT/University Cancer Center (UCC) Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Heining C; DKTK, Partner Site Dresden, Dresden, Germany.; Department of Translational Medical Oncology, NCT, NCT/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, Dresden, Germany., Teleanu MV; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany., Horak P; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany., Kreutzfeldt S; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany., Hübschmann D; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Computational Oncology Group, Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.; Innovation and Service Unit for Bioinformatics and Precision Medicine, DKFZ, Heidelberg, Germany.; Pattern Recognition and Digital Medicine Group, Heidelberg Institute for Stem Cell Technology and Experimental Medicine, Heidelberg, Germany., Hartmann W; Gerhard Domagk Institute of Pathology, Münster University Hospital, Münster, Germany., Glimm H; DKTK, Partner Site Dresden, Dresden, Germany.; Department of Translational Medical Oncology, NCT, NCT/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.; Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, Dresden, Germany.; Translational Functional Cancer Genomics, DKFZ, Heidelberg, Germany., Fröhling S; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. stefan.froehling@nct-heidelberg.de.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. stefan.froehling@nct-heidelberg.de.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany. stefan.froehling@nct-heidelberg.de.; Division of Translational Precision Medicine, Institute of Human Genetics, Heidelberg University, Heidelberg, Germany. stefan.froehling@nct-heidelberg.de. |
| Source: | Nature communications [Nat Commun] 2026 Apr 09; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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