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ARID1A deficiency reprograms the tumor secretome, enhancing microenvironmental remodeling and metastatic dissemination in endometrial carcinoma.

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Title: ARID1A deficiency reprograms the tumor secretome, enhancing microenvironmental remodeling and metastatic dissemination in endometrial carcinoma.
Authors: Megino-Luque C; Oncologic Pathology Group, Department of Medicine and Surgery, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain. cristina.meginoluque@mssm.edu.; Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. cristina.meginoluque@mssm.edu.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. cristina.meginoluque@mssm.edu., Albertí-Valls M; Oncologic Pathology Group, Department of Medicine and Surgery, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain., Olave S; Oncologic Pathology Group, Department of Medicine and Surgery, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Sisó P; Oncologic Pathology Group, Department of Experimental Medicine, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain., Bonifaci N; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Molecular Mechanisms and Experimental Therapy in Oncology-Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Gran via De l'Hospitalet 199, Barcelona, Spain., Macià A; Oncologic Pathology Group, Department of Experimental Medicine, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain., Matias-Guiu X; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Department of Pathology, Hospital Universitari Arnau de Vilanova, Lleida, Spain.; Oncologic Pathology Group, Department of Basic Medical Sciences, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain., Gatius S; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Department of Pathology, Hospital Universitari Arnau de Vilanova, Lleida, Spain.; Oncologic Pathology Group, Department of Basic Medical Sciences, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain., Llobet-Navas D; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Molecular Mechanisms and Experimental Therapy in Oncology-Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Gran via De l'Hospitalet 199, Barcelona, Spain., Eritja N; Oncologic Pathology Group, Department of Medicine and Surgery, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain. nuria.eritja@udl.cat.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. nuria.eritja@udl.cat.
Source: Cell death & disease [Cell Death Dis] 2026 Apr 10; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ARID1A deficiency reprograms the tumor secretome, enhancing microenvironmental remodeling and metastatic dissemination in endometrial carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Megino-Luque+C%22">Megino-Luque C</searchLink>; Oncologic Pathology Group, Department of Medicine and Surgery, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain. cristina.meginoluque@mssm.edu.; Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. cristina.meginoluque@mssm.edu.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. cristina.meginoluque@mssm.edu.<br /><searchLink fieldCode="AU" term="%22Albertí-Valls+M%22">Albertí-Valls M</searchLink>; Oncologic Pathology Group, Department of Medicine and Surgery, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain.<br /><searchLink fieldCode="AU" term="%22Olave+S%22">Olave S</searchLink>; Oncologic Pathology Group, Department of Medicine and Surgery, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sisó+P%22">Sisó P</searchLink>; Oncologic Pathology Group, Department of Experimental Medicine, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain.<br /><searchLink fieldCode="AU" term="%22Bonifaci+N%22">Bonifaci N</searchLink>; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Molecular Mechanisms and Experimental Therapy in Oncology-Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Gran via De l'Hospitalet 199, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Macià+A%22">Macià A</searchLink>; Oncologic Pathology Group, Department of Experimental Medicine, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain.<br /><searchLink fieldCode="AU" term="%22Matias-Guiu+X%22">Matias-Guiu X</searchLink>; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Department of Pathology, Hospital Universitari Arnau de Vilanova, Lleida, Spain.; Oncologic Pathology Group, Department of Basic Medical Sciences, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain.<br /><searchLink fieldCode="AU" term="%22Gatius+S%22">Gatius S</searchLink>; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Department of Pathology, Hospital Universitari Arnau de Vilanova, Lleida, Spain.; Oncologic Pathology Group, Department of Basic Medical Sciences, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain.<br /><searchLink fieldCode="AU" term="%22Llobet-Navas+D%22">Llobet-Navas D</searchLink>; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Molecular Mechanisms and Experimental Therapy in Oncology-Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Gran via De l'Hospitalet 199, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Eritja+N%22">Eritja N</searchLink>; Oncologic Pathology Group, Department of Medicine and Surgery, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, Lleida, Spain. nuria.eritja@udl.cat.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. nuria.eritja@udl.cat.
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      – TitleFull: ARID1A deficiency reprograms the tumor secretome, enhancing microenvironmental remodeling and metastatic dissemination in endometrial carcinoma.
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              Text: 2026 Apr 10
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