Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).

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Title: Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).
Authors: Tessier TM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. tessiert@chop.edu.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA. tessiert@chop.edu., Maitland MER; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Kutera M; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Dybas JM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA., St-Germain J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada., Zhang W; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada., Raught B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. brain.raught@gmail.com.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. brain.raught@gmail.com., Weitzman MD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. weitzmanm@chop.edu.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA. weitzmanm@chop.edu.
Source: Communications biology [Commun Biol] 2026 Apr 09; Vol. 9 (1). Date of Electronic Publication: 2026 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2399-3642
DOI:10.1038/s42003-026-09964-6