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Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).

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Title: Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).
Authors: Tessier TM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. tessiert@chop.edu.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA. tessiert@chop.edu., Maitland MER; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Kutera M; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Dybas JM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA., St-Germain J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada., Zhang W; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada., Raught B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. brain.raught@gmail.com.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. brain.raught@gmail.com., Weitzman MD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. weitzmanm@chop.edu.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA. weitzmanm@chop.edu.
Source: Communications biology [Commun Biol] 2026 Apr 09; Vol. 9 (1). Date of Electronic Publication: 2026 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).
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  Data: <searchLink fieldCode="AU" term="%22Tessier+TM%22">Tessier TM</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. tessiert@chop.edu.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA. tessiert@chop.edu.<br /><searchLink fieldCode="AU" term="%22Maitland+MER%22">Maitland MER</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kutera+M%22">Kutera M</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dybas+JM%22">Dybas JM</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22St-Germain+J%22">St-Germain J</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Arrowsmith+CH%22">Arrowsmith CH</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Barsyte-Lovejoy+D%22">Barsyte-Lovejoy D</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Raught+B%22">Raught B</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. brain.raught@gmail.com.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. brain.raught@gmail.com.<br /><searchLink fieldCode="AU" term="%22Weitzman+MD%22">Weitzman MD</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. weitzmanm@chop.edu.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA. weitzmanm@chop.edu.
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        Value: 10.1038/s42003-026-09964-6
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              Text: 2026 Apr 09
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