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An AI-derived peptide PCa2 suppresses pancreatic cancer growth via modulation of the ErbB/PI3K/AKT/mTOR/MYC signaling axis.

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Title: An AI-derived peptide PCa2 suppresses pancreatic cancer growth via modulation of the ErbB/PI3K/AKT/mTOR/MYC signaling axis.
Authors: Zuo W; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China., Luo S; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China., Qin H; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China., Wong KH; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China., Siu SWI; Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau, SAR, China., Tashima AK; Department of Biochemistry, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil., Assaraf YG; The Fred Wyszkowski Cancer Research Laboratory, Faculty of Biology, Technion-Israel Institute of Technology, Haifa, 3200002, Israel., Kwok HF; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China. hfkwok@um.edu.mo.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China. hfkwok@um.edu.mo.; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China. hfkwok@um.edu.mo.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2026 Apr 09; Vol. 24 (1). Date of Electronic Publication: 2026 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An AI-derived peptide PCa2 suppresses pancreatic cancer growth via modulation of the ErbB/PI3K/AKT/mTOR/MYC signaling axis.
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  Data: <searchLink fieldCode="AU" term="%22Zuo+W%22">Zuo W</searchLink>; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Luo+S%22">Luo S</searchLink>; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Qin+H%22">Qin H</searchLink>; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Wong+KH%22">Wong KH</searchLink>; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Siu+SWI%22">Siu SWI</searchLink>; Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau, SAR, China.<br /><searchLink fieldCode="AU" term="%22Tashima+AK%22">Tashima AK</searchLink>; Department of Biochemistry, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Assaraf+YG%22">Assaraf YG</searchLink>; The Fred Wyszkowski Cancer Research Laboratory, Faculty of Biology, Technion-Israel Institute of Technology, Haifa, 3200002, Israel.<br /><searchLink fieldCode="AU" term="%22Kwok+HF%22">Kwok HF</searchLink>; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China. hfkwok@um.edu.mo.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China. hfkwok@um.edu.mo.; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China. hfkwok@um.edu.mo.
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  Data: <searchLink fieldCode="JN" term="%22101170464%22">Cell communication and signaling : CCS</searchLink> [Cell Commun Signal] 2026 Apr 09; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Apr 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101170464 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1478-811X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221478811X%22">1478811X </searchLink><i>NLM ISO Abbreviation: </i>Cell Commun Signal <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12964-026-02856-6
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      – TitleFull: An AI-derived peptide PCa2 suppresses pancreatic cancer growth via modulation of the ErbB/PI3K/AKT/mTOR/MYC signaling axis.
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            – D: 09
              M: 04
              Text: 2026 Apr 09
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              Y: 2026
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