Generation of biologically responsive colon-like intestinal tissue patches from human induced pluripotent stem cells using a rapid co-differentiation platform.

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Title: Generation of biologically responsive colon-like intestinal tissue patches from human induced pluripotent stem cells using a rapid co-differentiation platform.
Authors: Dalleywater W; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK. william.dalleywater@nottingham.ac.uk.; Department of Cellular Pathology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK. william.dalleywater@nottingham.ac.uk., Predeus AV; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Cakir B; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Mazin P; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Vadakekolathu J; John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, UK., Rutella S; John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, UK., Meakin ML; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Ritchie AA; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Montazid S; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK., Ocaña SC; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Holmes N; School of Life Sciences, University of Nottingham, Nottingham, UK., Wright V; School of Life Sciences, University of Nottingham, Nottingham, UK., Sang F; School of Life Sciences, University of Nottingham, Nottingham, UK., Santoni S; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Bills A; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Sculthorpe D; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Elmentaite R; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Teichmann SA; Wellcome Sanger Institute, Hinxton, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Irshad S; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, Oxford, UK., Tomlinson I; Department of Oncology, University of Oxford, Oxford, UK., Silver A; Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Wildman RD; Faculty of Engineering, University of Nottingham, Nottingham, UK., Hannan NRF; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK. nick.hannan@nottingham.ac.uk., Rose FRAJ; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham, UK. felicity.rose@nottingham.ac.uk., Ilyas M; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK. mohammad.ilyas@nottingham.ac.uk.; Department of Cellular Pathology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK. mohammad.ilyas@nottingham.ac.uk.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 Apr 09; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
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  Data: Generation of biologically responsive colon-like intestinal tissue patches from human induced pluripotent stem cells using a rapid co-differentiation platform.
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  Data: <searchLink fieldCode="AU" term="%22Dalleywater+W%22">Dalleywater W</searchLink>; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK. william.dalleywater@nottingham.ac.uk.; Department of Cellular Pathology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK. william.dalleywater@nottingham.ac.uk.<br /><searchLink fieldCode="AU" term="%22Predeus+AV%22">Predeus AV</searchLink>; Wellcome Sanger Institute, Hinxton, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cakir+B%22">Cakir B</searchLink>; Wellcome Sanger Institute, Hinxton, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mazin+P%22">Mazin P</searchLink>; Wellcome Sanger Institute, Hinxton, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vadakekolathu+J%22">Vadakekolathu J</searchLink>; John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Rutella+S%22">Rutella S</searchLink>; John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Meakin+ML%22">Meakin ML</searchLink>; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Ritchie+AA%22">Ritchie AA</searchLink>; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Montazid+S%22">Montazid S</searchLink>; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ocaña+SC%22">Ocaña SC</searchLink>; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Holmes+N%22">Holmes N</searchLink>; School of Life Sciences, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Wright+V%22">Wright V</searchLink>; School of Life Sciences, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Sang+F%22">Sang F</searchLink>; School of Life Sciences, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Santoni+S%22">Santoni S</searchLink>; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Bills+A%22">Bills A</searchLink>; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Sculthorpe+D%22">Sculthorpe D</searchLink>; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Elmentaite+R%22">Elmentaite R</searchLink>; Wellcome Sanger Institute, Hinxton, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Teichmann+SA%22">Teichmann SA</searchLink>; Wellcome Sanger Institute, Hinxton, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Irshad+S%22">Irshad S</searchLink>; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tomlinson+I%22">Tomlinson I</searchLink>; Department of Oncology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Silver+A%22">Silver A</searchLink>; Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wildman+RD%22">Wildman RD</searchLink>; Faculty of Engineering, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Hannan+NRF%22">Hannan NRF</searchLink>; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK. nick.hannan@nottingham.ac.uk.<br /><searchLink fieldCode="AU" term="%22Rose+FRAJ%22">Rose FRAJ</searchLink>; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham, UK. felicity.rose@nottingham.ac.uk.<br /><searchLink fieldCode="AU" term="%22Ilyas+M%22">Ilyas M</searchLink>; Unit of Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK. mohammad.ilyas@nottingham.ac.uk.; Department of Cellular Pathology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK. mohammad.ilyas@nottingham.ac.uk.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101527581 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-6512 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217576512%22">17576512 </searchLink><i>NLM ISO Abbreviation: </i>Stem Cell Res Ther <i>Subsets: </i>MEDLINE
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