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A selective agonist of the prostacyclin receptor alleviates microglial and astroglial neuroinflammatory responses through P38 and NLRP3.

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Title: A selective agonist of the prostacyclin receptor alleviates microglial and astroglial neuroinflammatory responses through P38 and NLRP3.
Authors: Lee HJ; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Kang S; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Jeong YJ; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea., Jung TM; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Hwang JW; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Jang JY; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea., Gu CH; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Oh S; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Song JH; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Moon M; Research Institute for Dementia Science, Konyang University, Daejeon, Republic of Korea., Hoe HS; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea.
Source: Frontiers in immunology [Front Immunol] 2026 Mar 25; Vol. 17, pp. 1664119. Date of Electronic Publication: 2026 Mar 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A selective agonist of the prostacyclin receptor alleviates microglial and astroglial neuroinflammatory responses through P38 and NLRP3.
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  Data: <searchLink fieldCode="AU" term="%22Lee+HJ%22">Lee HJ</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+S%22">Kang S</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+YJ%22">Jeong YJ</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jung+TM%22">Jung TM</searchLink>; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hwang+JW%22">Hwang JW</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jang+JY%22">Jang JY</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Gu+CH%22">Gu CH</searchLink>; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+S%22">Oh S</searchLink>; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Song+JH%22">Song JH</searchLink>; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Moon+M%22">Moon M</searchLink>; Research Institute for Dementia Science, Konyang University, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hoe+HS%22">Hoe HS</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea.
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              Text: 2026 Mar 25
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