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Integrative phytochemical profiling and systems pharmacology identify ERBB2-MAPK1-AKT1 signaling as a molecular basis for the anti-vertigo effects of Ziyin Zhixuan Decoction.

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Title: Integrative phytochemical profiling and systems pharmacology identify ERBB2-MAPK1-AKT1 signaling as a molecular basis for the anti-vertigo effects of Ziyin Zhixuan Decoction.
Authors: Wang J; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China., Guo H; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China., Liu J; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China., Ren J; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China., Wang M; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China., Dai R; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China., Cao L; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China., Cao Y; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China., Yao W; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China.; Nanjing University of Chinese Medicine Hanlin College, Taizhou Key Laboratory of Traditional Chinese Medicine and Comprehensive Health Products Development, TaiZhou Engineering Research Center for Quality and Industrialization of Traditional Chinese Medicine, Taizhou, 225300, China., Yu H; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China., Zhao X; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China., Zhao F; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China., Bao B; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China., Zhang L; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China.; Nanjing University of Chinese Medicine Hanlin College, Taizhou Key Laboratory of Traditional Chinese Medicine and Comprehensive Health Products Development, TaiZhou Engineering Research Center for Quality and Industrialization of Traditional Chinese Medicine, Taizhou, 225300, China.
Source: Biochemistry and biophysics reports [Biochem Biophys Rep] 2026 Mar 27; Vol. 46, pp. 102557. Date of Electronic Publication: 2026 Mar 27 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101660999 Publication Model: eCollection Cited Medium: Internet ISSN: 2405-5808 (Electronic) Linking ISSN: 24055808 NLM ISO Abbreviation: Biochem Biophys Rep Subsets: PubMed not MEDLINE
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  Data: Integrative phytochemical profiling and systems pharmacology identify ERBB2-MAPK1-AKT1 signaling as a molecular basis for the anti-vertigo effects of Ziyin Zhixuan Decoction.
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  Data: <searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Guo+H%22">Guo H</searchLink>; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Ren+J%22">Ren J</searchLink>; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Dai+R%22">Dai R</searchLink>; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China.<br /><searchLink fieldCode="AU" term="%22Cao+L%22">Cao L</searchLink>; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Yao+W%22">Yao W</searchLink>; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China.; Nanjing University of Chinese Medicine Hanlin College, Taizhou Key Laboratory of Traditional Chinese Medicine and Comprehensive Health Products Development, TaiZhou Engineering Research Center for Quality and Industrialization of Traditional Chinese Medicine, Taizhou, 225300, China.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China.<br /><searchLink fieldCode="AU" term="%22Zhao+F%22">Zhao F</searchLink>; Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China.<br /><searchLink fieldCode="AU" term="%22Bao+B%22">Bao B</searchLink>; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Nanjing Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Centre of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing, 210023, China.; Nanjing University of Chinese Medicine Hanlin College, Taizhou Key Laboratory of Traditional Chinese Medicine and Comprehensive Health Products Development, TaiZhou Engineering Research Center for Quality and Industrialization of Traditional Chinese Medicine, Taizhou, 225300, China.
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