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Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation.

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Title: Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation.
Authors: Kubaczka C; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Kambli N; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Windisch R; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Yu K; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Zhao Y; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Wu S; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Frenis K; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA., Walcheck MT; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA., Falchetti M; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Najia M; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., LeBlanc ZC; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA., North TE; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA., Rowe RG; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA., Daley GQ; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Schlaeger TM; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 01. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41959015
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Efficient Generation of Functional TCRαβ<superscript>+</superscript> Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation.
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  Data: <searchLink fieldCode="AU" term="%22Kubaczka+C%22">Kubaczka C</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Kambli+N%22">Kambli N</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Windisch+R%22">Windisch R</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Yu+K%22">Yu K</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Frenis+K%22">Frenis K</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Walcheck+MT%22">Walcheck MT</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Falchetti+M%22">Falchetti M</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Najia+M%22">Najia M</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22LeBlanc+ZC%22">LeBlanc ZC</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22North+TE%22">North TE</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rowe+RG%22">Rowe RG</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Daley+GQ%22">Daley GQ</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Schlaeger+TM%22">Schlaeger TM</searchLink>; Stem Cell and Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.
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        Value: 10.64898/2026.03.31.715684
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              Text: 2026 Apr 01
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