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Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses.

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Title: Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses.
Authors: Geisler HC; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Safford HC; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Thatte AS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Padilla MS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Battistini E; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Yamagata HM; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Ullman VM; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Chan A; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Nachod BE; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Agrawal A; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Watkins MB; The Biophysics Collaborative Access Team (BioCAT), Department of Physics, Illinois Institute of Technology, Chicago, IL 60616, USA., Hopkins JB; The Biophysics Collaborative Access Team (BioCAT), Department of Physics, Illinois Institute of Technology, Chicago, IL 60616, USA., Tsourkas A; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Gupta K; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 08. Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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              Text: 2026 Apr 08
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